{"id":"W4312194739","doi":"10.3390/ijms232415888","title":"Donor Genetic Predisposition to High Interleukin-10 Production Appears Protective against Acute Graft-Versus-Host Disease","year":2022,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Health Services; Calgary Laboratory Services; University of Calgary","funders":"Alberta Cancer Foundation; Mach-Gaensslen Foundation of Canada; Calgary Laboratory Services","keywords":"Interleukin 10; Immunology; Graft-versus-host disease; Human leukocyte antigen; Transplantation; CD8; Genotype; Biology; Hematopoietic stem cell transplantation; Immune system; Medicine; Gene; Antigen; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002880039,0.0002351212,0.0002332141,0.0002494922,0.0001090447,0.0002860918,0.0001051367,0.0001624516,0.001768256],"category_scores_gemma":[0.0003459393,0.00009894022,0.0001375717,0.0001360818,0.0001712719,0.00008806847,0.0001813768,0.0003070839,0.0002529578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007440984,"about_ca_system_score_gemma":0.0001299798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001161428,"about_ca_topic_score_gemma":0.0001544221,"domain_scores_codex":[0.9998195,0.00006865925,0.00001271438,0.00003501926,0.00002224921,0.00004186722],"domain_scores_gemma":[0.9995241,0.0001097591,0.0001411345,0.00005310163,0.00001613785,0.0001559046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001676158,0.0002663135,0.1507585,0.00005763626,0.00004783334,0.0005781039,0.00005989229,0.0001375844,0.8404483,0.000130199,0.00007817941,0.005761464],"study_design_scores_gemma":[0.00009849826,0.003976894,0.8638397,0.00002823939,0.0001611948,0.007762432,0.0001991717,0.001159648,0.1209759,0.0002778039,0.001505897,0.00001464677],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992608,0.00009723388,0.0002915583,0.00001422404,0.00000481594,0.000003187395,0.00002617134,0.00001145085,0.0002904936],"genre_scores_gemma":[0.9995021,0.00006170085,0.0001806775,0.00001705249,0.000005828533,0.000003362469,0.00005399024,0.00000387147,0.0001712944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001768256,"threshold_uncertainty_score":0.005915403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01180507542945301,"score_gpt":0.2811198553160794,"score_spread":0.2693147798866264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}