{"id":"W4312196389","doi":"10.3390/cells11244132","title":"PCSK9 in Liver Cancers at the Crossroads between Lipid Metabolism and Immunity","year":2022,"lang":"en","type":"review","venue":"Cells","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"PCSK9; Proprotein convertase; Kexin; Biology; Lipid metabolism; LDL receptor; Immune system; Cancer research; Immunology; Cholesterol; Lipoprotein; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004946522,0.0003970569,0.0009903804,0.00007471474,0.0002347956,0.00004349828,0.000510208,0.0003223904,0.0003653438],"category_scores_gemma":[0.00003445892,0.0002989825,0.0003637241,0.0001937947,0.0002410068,0.000003477549,0.0008246297,0.0005166107,0.000021159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001347527,"about_ca_system_score_gemma":0.000469641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001018707,"about_ca_topic_score_gemma":0.0005441813,"domain_scores_codex":[0.9981098,0.0003780019,0.0004116643,0.0005428928,0.0001676196,0.0003899794],"domain_scores_gemma":[0.998807,0.00008028046,0.0002302915,0.0007583692,0.00002174646,0.0001022742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000182042,0.00001971698,0.00001528281,0.001476084,0.0002109123,5.366448e-7,0.0001899503,0.000003547407,0.0006107209,0.00001038393,0.03726538,0.9601793],"study_design_scores_gemma":[0.0002724466,0.00002435512,0.00006452415,0.000141304,0.0004086382,0.000009693924,0.00003176958,2.4494e-7,0.0003469262,0.000002492239,0.9983526,0.0003449579],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00113094,0.9908759,0.000002378389,0.00001068903,0.005850634,0.0005504636,0.0003712332,0.000007569601,0.001200211],"genre_scores_gemma":[0.00003210254,0.9825807,0.00001397042,0.0001279288,0.01002207,0.0001793174,0.0004687706,0.00006000373,0.00651513],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9610873,"threshold_uncertainty_score":0.9999462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03199126756134574,"score_gpt":0.2943962756868482,"score_spread":0.2624050081255025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}