{"id":"W4312197263","doi":"10.1101/2022.12.21.521533","title":"Senescent response in inner annulus fibrosus cells in response to TNFα, H <sub>2</sub> O <sub>2</sub> , and TNFα-induced nucleus pulposus senescent secretome","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Spine and Intervertebral Disc Pathology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"","keywords":"Senescence; Cell biology; Tumor necrosis factor alpha; SOD2; Paracrine signalling; Biology; Cell; Chemistry; Superoxide dismutase; Immunology; Oxidative stress; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002282223,0.0002886136,0.0003760775,0.0002496502,0.0001443822,0.0002497682,0.00008201602,0.0002318937,0.001054221],"category_scores_gemma":[0.0001030737,0.0001347434,0.0002599938,0.0001599124,0.0002561671,0.0001663459,0.0001398154,0.0004957249,0.0002962468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001801078,"about_ca_system_score_gemma":0.0001305221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005180583,"about_ca_topic_score_gemma":0.0005358122,"domain_scores_codex":[0.9998488,0.00002552165,0.00002387511,0.00002786304,0.00003775,0.00003611372],"domain_scores_gemma":[0.9998072,0.00003285441,0.00005581857,0.00001989314,0.00002691739,0.00005734164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001832078,0.00002282231,0.0002498963,0.0000261821,0.000002377041,0.00007296079,0.00003515166,0.000009862903,0.9991236,0.00001327159,0.00001061834,0.0002501126],"study_design_scores_gemma":[0.00002934085,0.001146975,0.02778496,0.00001178334,0.00001808812,0.0005837961,0.0002530339,0.0005785167,0.9680244,0.00003960235,0.001521916,0.000007632492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965933,0.001193661,0.001039433,0.00004844765,0.00003900274,0.00002708425,0.0003023754,0.00003147202,0.0007252879],"genre_scores_gemma":[0.9944958,0.0007278564,0.00128299,0.00008103711,0.00002492618,0.00006346696,0.0005832633,0.000009423694,0.002731202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001054221,"threshold_uncertainty_score":0.003526747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01475383710168735,"score_gpt":0.2435636833876177,"score_spread":0.2288098462859303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}