{"id":"W4312197420","doi":"10.3803/enm.2022.1563","title":"BRAFV600E Mutation Enhances Estrogen-Induced Metastatic Potential of Thyroid Cancer by Regulating the Expression of Estrogen Receptors","year":2022,"lang":"en","type":"article","venue":"Endocrinology and Metabolism","topic":"Thyroid Cancer Diagnosis and Treatment","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Seoul National University Hospital; National Research Foundation of Korea; Seoul National University; Ministry of Science, ICT and Future Planning; National Research Foundation; American Thyroid Association","keywords":"Medicine; Estrogen receptor; Estrogen; Cancer research; Estrogen-related receptor alpha; Estrogen receptor alpha; Estrogen receptor beta; Internal medicine; Thyroid cancer; Thyroid; Oncology; Mutation; Cancer; Endocrinology; Breast cancer; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001172941,0.0001440731,0.0004083173,0.00007585107,0.0001922584,0.000003840552,0.00009249979,0.00002665557,0.0002457589],"category_scores_gemma":[0.00003040931,0.00009959602,0.0001039866,0.0001424557,0.0001247496,0.0000541152,0.00009338318,0.0001731313,5.825631e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002614461,"about_ca_system_score_gemma":0.00008418166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00032602,"about_ca_topic_score_gemma":0.000005710396,"domain_scores_codex":[0.9987396,0.0002022997,0.000337979,0.0002465709,0.0002416296,0.000231909],"domain_scores_gemma":[0.9992998,0.00008782706,0.0003060682,0.0002021934,0.00005281368,0.00005131347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003836451,0.0003589494,0.003245842,0.00005864963,0.0004981052,0.00002139505,0.001399806,0.000164652,0.9492027,0.002711349,0.0009635953,0.04099138],"study_design_scores_gemma":[0.00249812,0.0003473398,0.006218025,0.00002510206,0.0006604014,0.0001092811,0.001647361,0.00002414382,0.9824049,0.0002684328,0.005703439,0.00009343286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9522699,0.04591342,0.00003395943,0.0007862268,0.0005082362,0.000352699,0.00006382864,0.00001628072,0.00005541336],"genre_scores_gemma":[0.9970832,0.001801018,0.0004442653,0.00009961326,0.00007973608,0.0003208762,0.00003883083,0.0000146859,0.000117737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0448133,"threshold_uncertainty_score":0.4061408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0133422573829779,"score_gpt":0.2788844302206527,"score_spread":0.2655421728376748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}