{"id":"W4312197420","doi":"10.3803/enm.2022.1563","title":"BRAFV600E Mutation Enhances Estrogen-Induced Metastatic Potential of Thyroid Cancer by Regulating the Expression of Estrogen Receptors","year":2022,"lang":"en","type":"article","venue":"Endocrinology and Metabolism","topic":"Thyroid Cancer Diagnosis and Treatment","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Seoul National University Hospital; National Research Foundation of Korea; Seoul National University; Ministry of Science, ICT and Future Planning; National Research Foundation; American Thyroid Association","keywords":"Medicine; Estrogen receptor; Estrogen; Cancer research; Estrogen-related receptor alpha; Estrogen receptor alpha; Estrogen receptor beta; Internal medicine; Thyroid cancer; Thyroid; Oncology; Mutation; Cancer; Endocrinology; Breast cancer; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009488467,0.0001635451,0.0001580825,0.0001870139,0.000124183,0.0001395348,0.0001325621,0.0001743878,0.001448822],"category_scores_gemma":[0.00008628883,0.00009720861,0.0002022653,0.0001267399,0.0001935956,0.00009952187,0.0001118557,0.0002689802,0.0002660194],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003033723,"about_ca_system_score_gemma":0.0001904395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001438865,"about_ca_topic_score_gemma":0.002576956,"domain_scores_codex":[0.999923,0.00000966992,0.000007549767,0.00001303963,0.00002553318,0.00002125165],"domain_scores_gemma":[0.9999515,0.000008569296,0.00001071127,0.00000630738,0.000007281744,0.00001561312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007218345,0.00002155537,0.0005392084,0.00001626666,0.000002326984,0.00006222584,0.000009589945,0.00002159265,0.9986286,0.00004567652,0.00004841613,0.0005323603],"study_design_scores_gemma":[0.00003903355,0.0007916033,0.02115643,0.000005511728,0.00002987693,0.0009850371,0.00007359048,0.0007255987,0.9718552,0.00007557692,0.00425692,0.000005594863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970498,0.0005307465,0.0005850677,0.00007164241,0.00001043776,0.00002692882,0.0002711912,0.00003282983,0.001421302],"genre_scores_gemma":[0.9959552,0.0005248655,0.0009372953,0.0000371514,0.000005501422,0.00003130667,0.0004589925,0.00001169965,0.002038065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001448822,"threshold_uncertainty_score":0.004846752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0133422573829779,"score_gpt":0.2788844302206527,"score_spread":0.2655421728376748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}