{"id":"W4312201105","doi":"10.1038/s41467-022-35649-9","title":"PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Cancer Institute; National Institutes of Health; Norges Forskningsråd; Helse Vest; Kreftforeningen; Elsa U. Pardee Foundation","keywords":"Tumor microenvironment; Tumor progression; Cancer research; LRP1; Psychological repression; Biology; Secretion; Cancer; Cell biology; Tumor cells; Genetics; LDL receptor; Lipoprotein; Biochemistry; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002236376,0.00009691677,0.0001130895,0.00003308033,0.0003826092,0.000009247794,0.0006514494,0.0000521869,0.00000811565],"category_scores_gemma":[0.0000634344,0.00007450364,0.0000481058,0.0001052094,0.0001074812,0.00000337031,0.001409713,0.0003628107,6.346603e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001520415,"about_ca_system_score_gemma":0.00003917539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002175835,"about_ca_topic_score_gemma":0.00002537077,"domain_scores_codex":[0.9991478,0.0001832107,0.0001779247,0.0002214078,0.0001489195,0.0001207718],"domain_scores_gemma":[0.9984164,0.00002789619,0.0001188035,0.001344575,0.00003947272,0.00005286367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001106203,0.0001467395,0.000842241,0.00001267495,0.00002418905,6.502025e-8,0.0002609828,0.0002096075,0.9820482,0.000381522,0.01282708,0.003136058],"study_design_scores_gemma":[0.0005341349,0.0001946969,0.01115901,0.00003026036,0.00005256111,0.00004067267,0.0001792503,0.0004546217,0.07849713,0.0002149598,0.9084489,0.0001938322],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9251685,0.06138685,0.0005000066,0.008642022,0.001609283,0.001456811,0.0001750685,0.00002652764,0.001034915],"genre_scores_gemma":[0.9941812,0.0009575713,0.003217116,0.0009662463,0.0002981143,0.0001518834,0.00009700405,0.00001577524,0.0001150458],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9035511,"threshold_uncertainty_score":0.303817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008985780132482819,"score_gpt":0.2827227333638244,"score_spread":0.2737369532313416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}