{"id":"W4312201105","doi":"10.1038/s41467-022-35649-9","title":"PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Cancer Institute; National Institutes of Health; Norges Forskningsråd; Helse Vest; Kreftforeningen; Elsa U. Pardee Foundation","keywords":"Tumor microenvironment; Tumor progression; Cancer research; LRP1; Psychological repression; Biology; Secretion; Cancer; Cell biology; Tumor cells; Genetics; LDL receptor; Lipoprotein; Biochemistry; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001723246,0.0003160413,0.000171127,0.0001569572,0.0001352098,0.0003985116,0.0001435262,0.0002792825,0.001291409],"category_scores_gemma":[0.0001254466,0.0001166556,0.0002395525,0.0001072542,0.0002114325,0.0001862233,0.0002208836,0.000500718,0.0004702292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003415494,"about_ca_system_score_gemma":0.0002156457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004213925,"about_ca_topic_score_gemma":0.0006422333,"domain_scores_codex":[0.9998604,0.0000315621,0.00000825715,0.00002336336,0.0000420241,0.00003437593],"domain_scores_gemma":[0.9999151,0.00001123094,0.0000250887,0.00001352154,0.00001336465,0.00002176414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003568408,0.000008343201,0.0001539167,0.00001678213,0.000002034374,0.00005786262,0.000006554052,0.00010139,0.9986045,0.0002375376,0.00007270955,0.000702628],"study_design_scores_gemma":[0.0000192513,0.0002440417,0.004510497,0.00000724945,0.000006172993,0.0006234818,0.00003995401,0.002287306,0.9847391,0.000207092,0.007310013,0.000005831189],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9769334,0.004930528,0.01044992,0.0008922027,0.000132844,0.00003947333,0.0004096351,0.0003454395,0.00586656],"genre_scores_gemma":[0.9931144,0.001178759,0.002156667,0.0001117135,0.00002807712,0.00001732759,0.0002871712,0.00002103749,0.003084906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001291409,"threshold_uncertainty_score":0.004320145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008985780132482819,"score_gpt":0.2827227333638244,"score_spread":0.2737369532313416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}