{"id":"W4312202064","doi":"10.1186/s13059-022-02837-1","title":"Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis","year":2022,"lang":"en","type":"review","venue":"Genome biology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Global Health Research; Université de Montréal; Université Laval; Montreal Heart Institute","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute on Aging; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Economic and Social Research Council; Cancer Research UK; Novo Nordisk Fonden; Medical Research Council; Public Health Agency; U.S. Department of Veterans Affairs; National Institute for Health and Care Research; National Institutes of Health; U.S. Department of Health and Human Services; National Cancer Institute; British Heart Foundation; National Human Genome Research Institute; Wellcome Trust","keywords":"Biology; Sexual dimorphism; Pleiotropy; Meta-analysis; Human genetics; Genetics; Evolutionary biology; Gene; Computational biology; Phenotype; Zoology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005872834,0.001297781,0.003660742,0.003132272,0.0001961402,0.001401472,0.001659211,0.001344178,0.002558104],"category_scores_gemma":[0.009036393,0.0004520549,0.0042537,0.003918889,0.000418976,0.0005666691,0.0008375674,0.001376545,0.0003789176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007468811,"about_ca_system_score_gemma":0.001677509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002093041,"about_ca_topic_score_gemma":0.003581815,"domain_scores_codex":[0.9978847,0.001078812,0.0002602401,0.0004177229,0.0002783026,0.00008008155],"domain_scores_gemma":[0.9912758,0.007221549,0.0006371968,0.0002993847,0.0004394987,0.0001265741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001654378,0.00006688425,0.0358055,0.09287409,0.09949297,0.00114736,0.0001323498,0.003268821,0.001612264,0.004962385,0.01629186,0.7426912],"study_design_scores_gemma":[0.001169495,0.001185738,0.1530387,0.06776947,0.3920068,0.01029722,0.0003640526,0.007507223,0.00480698,0.04133209,0.3201157,0.0004065039],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001159775,0.9956596,0.001696182,0.0006708542,0.0001322042,0.0000168661,0.0002561594,0.00002919797,0.0003790667],"genre_scores_gemma":[0.02693644,0.9675697,0.003533942,0.000655893,0.0003583376,0.0000710602,0.0005311897,0.00002820335,0.0003152536],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005872834,"threshold_uncertainty_score":0.03105885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1934604734579143,"score_gpt":0.3792072782055625,"score_spread":0.1857468047476483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}