{"id":"W4312203731","doi":"10.1038/s41467-022-35601-x","title":"Continuous cholinergic-dopaminergic updating in the nucleus accumbens underlies approaches to reward-predicting cues","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Western University","funders":"Canadian Institutes of Health Research; Canada First Research Excellence Fund; Canadian Institute for Advanced Research","keywords":"Nucleus accumbens; Neuroscience; Dopaminergic; Vesicular acetylcholine transporter; Dopamine; Acetylcholine; Neurochemical; Cholinergic; Medium spiny neuron; Dopamine transporter; Psychology; Striatum; Biology; Pharmacology; Choline acetyltransferase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007446873,0.000129008,0.0001294776,0.00006981086,0.0006521856,0.00005980609,0.001502386,0.0001192624,0.00002891382],"category_scores_gemma":[0.0001938555,0.000110583,0.00006790627,0.0003103928,0.00004242378,0.000005785376,0.0009720503,0.0007963394,0.000002503215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002985477,"about_ca_system_score_gemma":0.00004130741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004894904,"about_ca_topic_score_gemma":0.0003952803,"domain_scores_codex":[0.9987359,0.0003627741,0.0002433704,0.0002503854,0.0001926495,0.000214914],"domain_scores_gemma":[0.9985078,0.0000959487,0.00009768159,0.001217559,0.00004247974,0.00003853101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002284369,0.001608157,0.03936799,0.00005303114,0.0003387233,0.00001828611,0.01716608,0.04327462,0.6725946,0.1723378,0.03644041,0.01657186],"study_design_scores_gemma":[0.001325211,0.00062618,0.005452371,0.00004483143,0.00008014753,0.0001364637,0.06827939,0.006358096,0.01849393,0.00129507,0.8969085,0.0009998269],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799436,0.004807131,0.0002862441,0.005451757,0.0002089333,0.000445685,0.00007833124,0.00004059814,0.008737688],"genre_scores_gemma":[0.9920508,0.0001488731,0.005451934,0.001378822,0.0001239948,0.0002085472,0.0004695478,0.00002342801,0.0001440908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8604681,"threshold_uncertainty_score":0.501615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05938093382806944,"score_gpt":0.2872056278521095,"score_spread":0.22782469402404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}