{"id":"W4312209855","doi":"10.3390/ijms232416020","title":"Structural Polymorphism of Guanine Quadruplex-Containing Regions in Human Promoters","year":2022,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"G-quadruplex; Promoter; Guanine; Genetics; DNA; Biology; Gene; Nucleic acid; Human genome; Polymorphism (computer science); Genome; Intramolecular force; Computational biology; Allele; Gene expression; Chemistry; Stereochemistry; Nucleotide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001557943,0.0001340717,0.0002785659,0.001214546,0.000204474,0.000239851,0.0001139169,0.0002276212,0.0006216919],"category_scores_gemma":[0.0006749349,0.0001547246,0.0002584368,0.0008397819,0.0002058821,0.0001445995,0.0001993254,0.0001753833,0.0003017273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001103506,"about_ca_system_score_gemma":0.0001680714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004232434,"about_ca_topic_score_gemma":0.0007454341,"domain_scores_codex":[0.9997947,0.00004443666,0.00001957543,0.00007872978,0.00003918284,0.00002346118],"domain_scores_gemma":[0.9993497,0.0002028197,0.0002698151,0.00004663043,0.0000582882,0.00007282059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008894405,0.0000510279,0.1883398,0.0002786423,0.0001768568,0.0005825797,0.000480808,0.001381092,0.7876488,0.000355415,0.0001969403,0.01961859],"study_design_scores_gemma":[0.00003121832,0.0006283243,0.8434995,0.00005040263,0.0002848625,0.004951119,0.0004423523,0.006367426,0.1380604,0.001295475,0.004327548,0.00006141793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964325,0.0007382807,0.001922069,0.00002244064,0.000002530065,0.00001255973,0.0005448948,0.00004650358,0.0002783183],"genre_scores_gemma":[0.9963111,0.0002040306,0.002475645,0.00002447542,0.000005175301,0.00001426501,0.0007758356,0.000009234246,0.0001801359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001214546,"threshold_uncertainty_score":0.002079785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01432568104481305,"score_gpt":0.2864478741962095,"score_spread":0.2721221931513965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}