{"id":"W4312209891","doi":"10.3390/metabo12121284","title":"Cancer Cachexia and Dysregulated Phosphate Metabolism: Insights from Mutant p53 and Mutant Klotho Mouse Models","year":2022,"lang":"en","type":"article","venue":"Metabolites","topic":"Parathyroid Disorders and Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Cachexia; Klotho; Carcinogenesis; Biology; Cancer; Cancer research; Wasting; Anabolism; Endocrinology; Internal medicine; Medicine; Kidney; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008418543,0.0003363058,0.0007134075,0.0001464953,0.000311642,0.00005108368,0.00009000558,0.00006675506,0.0001587965],"category_scores_gemma":[0.00001937753,0.0002664582,0.00008244303,0.0003033957,0.000111115,0.0002041671,0.0001761393,0.0002121205,0.000005714065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004635071,"about_ca_system_score_gemma":0.00009588021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003037424,"about_ca_topic_score_gemma":0.00007435789,"domain_scores_codex":[0.9982604,0.0001078534,0.0003242304,0.0005849524,0.0003701654,0.0003524022],"domain_scores_gemma":[0.9991546,0.0000503268,0.0001184495,0.0003453159,0.00006403411,0.0002672561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002779332,0.002569475,0.04281422,0.00007046435,0.005047155,0.0009168884,0.01645743,0.001937015,0.8952685,0.01638654,0.001547959,0.01420502],"study_design_scores_gemma":[0.04289196,0.0006445815,0.2172681,0.0000594747,0.007873252,0.0002630428,0.00369778,0.07151525,0.4795846,0.04401767,0.1298033,0.002381017],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7061629,0.2923906,0.00002420022,0.0002393603,0.0001186299,0.0003680495,0.0003896227,0.00006887226,0.0002377978],"genre_scores_gemma":[0.9901869,0.007367273,0.0004372604,0.000625224,0.00006681043,0.0001412519,0.0001505633,0.00005300459,0.000971688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4156839,"threshold_uncertainty_score":0.9999788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01681712642242308,"score_gpt":0.2523710729292239,"score_spread":0.2355539465068009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}