{"id":"W4312211783","doi":"10.1177/17588359221143975","title":"Circulating tumor DNA in early-stage colon cancer: ready for prime time or needing refinement?","year":2022,"lang":"en","type":"review","venue":"Therapeutic Advances in Medical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"BC Cancer Foundation; Michael Smith Health Research BC","keywords":"Medicine; Liquid biopsy; Colorectal cancer; Stage (stratigraphy); Oncology; Minimal residual disease; Circulating tumor DNA; Internal medicine; Cancer; Clinical trial; Disease; Adjuvant; Leukemia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001110974,0.0004203653,0.001534707,0.0001755456,0.00008970885,0.00001406874,0.0006373194,0.0005267427,0.0007967008],"category_scores_gemma":[0.0006754167,0.0003664268,0.0002024946,0.0003170343,0.0001826895,0.000006981978,0.0003304794,0.0006374899,0.000006013945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000759058,"about_ca_system_score_gemma":0.002503449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000104641,"about_ca_topic_score_gemma":0.0009028848,"domain_scores_codex":[0.9969423,0.0002928978,0.001049899,0.0007546744,0.0003076685,0.0006526039],"domain_scores_gemma":[0.9978536,0.001023636,0.0005739742,0.0003629455,0.00003372608,0.0001521258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002700476,0.0001677278,0.00003094666,0.001325633,0.00008390372,0.0001605213,0.00006464015,0.00004123336,0.00007422281,0.0001553949,0.00009775169,0.997528],"study_design_scores_gemma":[0.001419169,0.001237071,0.000003141909,0.0009480476,0.0001409238,0.00005569835,0.00005504446,0.000154038,0.00001844234,0.00009066029,0.9954671,0.0004106507],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007788051,0.9953741,0.0001764292,0.0001381445,0.0008667315,0.001436418,0.0001822442,0.00001494278,0.001032174],"genre_scores_gemma":[0.0001674099,0.9947389,0.0004132824,0.001064757,0.0006796758,0.001946664,0.0004486596,0.00009086957,0.0004497454],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9971173,"threshold_uncertainty_score":0.9998788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06832000875268691,"score_gpt":0.4248725844434207,"score_spread":0.3565525756907338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}