{"id":"W4312222178","doi":"10.1016/j.ajo.2022.12.022","title":"AAV2-Mediated Gene Therapy for Choroideremia: 5-Year Results and Alternate Anti-sense Oligonucleotide Therapy","year":2022,"lang":"en","type":"article","venue":"American Journal of Ophthalmology","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Foundation Fighting Blindness; Canada Foundation for Innovation","keywords":"Choroideremia; Medicine; Ophthalmology; Retinal pigment epithelium; Visual acuity; Retinal; Genetic enhancement; Fundus (uterus); Fundus photography; Fluorescein angiography; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001605701,0.0008645963,0.0009328133,0.000778846,0.000374786,0.0006372645,0.0004918925,0.001357858,0.002161892],"category_scores_gemma":[0.0005815316,0.0001343616,0.001340473,0.0003148816,0.0007398147,0.0006356979,0.000260642,0.001015014,0.0005719204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000462651,"about_ca_system_score_gemma":0.0004537358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001272129,"about_ca_topic_score_gemma":0.001029788,"domain_scores_codex":[0.9994237,0.0001062857,0.00006481696,0.00009292209,0.0001232667,0.0001889568],"domain_scores_gemma":[0.9995664,0.0001172932,0.00005782023,0.0000843277,0.0000595845,0.0001146251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0143654,0.01462572,0.01578132,0.0007226335,0.0009484196,0.01600786,0.0009235099,0.004330818,0.4809893,0.00377069,0.004490339,0.443044],"study_design_scores_gemma":[0.00457465,0.1286947,0.179688,0.0003867871,0.003279282,0.05837058,0.0006554463,0.01276383,0.5316784,0.004487076,0.07494978,0.0004714177],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.934103,0.02313125,0.02704842,0.001176676,0.0006308514,0.0003332233,0.0008981923,0.0006706345,0.01200787],"genre_scores_gemma":[0.9771857,0.007009536,0.003751246,0.0006737111,0.0001805421,0.0001024614,0.001226753,0.0001242393,0.009745724],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002161892,"threshold_uncertainty_score":0.008491874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01332948942855345,"score_gpt":0.2700210952835303,"score_spread":0.2566916058549769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}