{"id":"W4312222178","doi":"10.1016/j.ajo.2022.12.022","title":"AAV2-Mediated Gene Therapy for Choroideremia: 5-Year Results and Alternate Anti-sense Oligonucleotide Therapy","year":2022,"lang":"en","type":"article","venue":"American Journal of Ophthalmology","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Foundation Fighting Blindness; Canada Foundation for Innovation","keywords":"Choroideremia; Medicine; Ophthalmology; Retinal pigment epithelium; Visual acuity; Retinal; Genetic enhancement; Fundus (uterus); Fundus photography; Fluorescein angiography; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004772738,0.0001670543,0.0003221588,0.0001057507,0.0001354808,0.00001501462,0.0002134089,0.00004513327,0.00003552953],"category_scores_gemma":[0.00009113867,0.0001471772,0.0001234059,0.0001277524,0.0002180199,0.000005715368,0.00008420309,0.0001675033,0.000001149509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001499696,"about_ca_system_score_gemma":0.0001201053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002604565,"about_ca_topic_score_gemma":2.561173e-7,"domain_scores_codex":[0.9987216,0.0001821907,0.0004053284,0.0002622542,0.0001512504,0.0002774041],"domain_scores_gemma":[0.9990306,0.0000721936,0.0004998324,0.0001680417,0.0001253241,0.0001039751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0198655,0.0004122551,0.09110806,0.000008153525,0.0007602533,0.0009415146,0.0005276969,0.0003270289,0.8603657,0.00003647334,0.004705852,0.02094145],"study_design_scores_gemma":[0.04488836,0.07155339,0.362437,0.0000313018,0.0001009799,0.1002044,0.00504288,0.0001137156,0.2360035,0.00181039,0.1755022,0.002311889],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965412,0.001731316,0.00004416758,0.0007523311,0.0002365795,0.0001735165,0.00003624184,0.000003710917,0.0004809364],"genre_scores_gemma":[0.9946984,0.003071588,0.00136335,0.0004685206,0.0001418486,0.00001439908,0.00006200401,0.0000307387,0.00014914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6243622,"threshold_uncertainty_score":0.6001711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01332948942855345,"score_gpt":0.2700210952835303,"score_spread":0.2566916058549769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}