{"id":"W4312233458","doi":"10.7554/elife.78550.sa2","title":"Author response: Autoantibody discovery across monogenic, acquired, and COVID-19-associated autoimmunity with scalable PhIP-seq","year":2022,"lang":"en","type":"peer-review","venue":"","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"Autoantibody; Autoimmunity; Immunology; Disease; Computational biology; Antigen; Biology; Antibody; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009675702,0.001289116,0.001068957,0.001132173,0.001660519,0.002950344,0.001785212,0.00595932,0.1525489],"category_scores_gemma":[0.04814385,0.0008130532,0.001580584,0.0008145343,0.0009920123,0.001841817,0.002843376,0.005575096,0.04824411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001389868,"about_ca_system_score_gemma":0.003455758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00172913,"about_ca_topic_score_gemma":0.004491471,"domain_scores_codex":[0.9949195,0.001888401,0.0005042508,0.0007567161,0.001511807,0.0004192993],"domain_scores_gemma":[0.9673022,0.01419074,0.00119679,0.002045868,0.01186626,0.003398182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001721691,0.00001443648,0.000380415,0.0001204209,0.00001581581,0.00006831128,0.00003206962,0.00009968622,0.0003082972,0.0002460124,0.9921004,0.006441907],"study_design_scores_gemma":[0.0005386692,0.0001508836,0.001693481,0.0004224554,0.0000542645,0.0002574758,0.0003998572,0.001110569,0.002019938,0.00451538,0.9887294,0.0001076265],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.004626528,0.002216748,0.02068977,0.496136,0.3760025,0.001496886,0.042524,0.01421469,0.04209287],"genre_scores_gemma":[0.03810113,0.003296677,0.04106341,0.5989622,0.1032696,0.004110282,0.02951567,0.007463942,0.1742172],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1525489,"threshold_uncertainty_score":0.5103268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03311615634252496,"score_gpt":0.3320766060219594,"score_spread":0.2989604496794344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}