{"id":"W4312233458","doi":"10.7554/elife.78550.sa2","title":"Author response: Autoantibody discovery across monogenic, acquired, and COVID-19-associated autoimmunity with scalable PhIP-seq","year":2022,"lang":"en","type":"peer-review","venue":"","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"Autoantibody; Autoimmunity; Immunology; Disease; Computational biology; Antigen; Biology; Antibody; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity"],"category_scores_codex":[0.0055176,0.001373394,0.002430885,0.0003396074,0.003676689,0.0002571599,0.001760478,0.001375695,0.01183376],"category_scores_gemma":[0.002407599,0.001148763,0.0005730235,0.001176718,0.001940875,0.0005227373,0.001752942,0.002346642,0.0003002333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007253003,"about_ca_system_score_gemma":0.002853228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005029843,"about_ca_topic_score_gemma":0.000230191,"domain_scores_codex":[0.9912844,0.003283903,0.001439747,0.001662825,0.0003623997,0.001966724],"domain_scores_gemma":[0.9951741,0.001374406,0.001136693,0.001978321,0.0002627193,0.00007380459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.006187702,0.001663039,0.0002357155,0.002575748,0.003174601,0.0001508201,0.002555385,0.00009495569,0.01235098,0.0003776229,0.9655378,0.005095653],"study_design_scores_gemma":[0.003535571,0.0008296474,0.002664997,0.0009415873,0.0006485742,0.0003633625,0.002005731,0.0000141595,0.0002483636,0.00007671328,0.9870885,0.001582784],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"other","genre_scores_codex":[0.04924215,0.8492107,0.0003770453,0.07938372,0.005382834,0.003263231,0.008350708,0.001294519,0.003495123],"genre_scores_gemma":[0.05956769,0.007890967,0.0000187764,0.00825321,0.000009648847,0.0004691471,0.013135,0.0001934046,0.9104621],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.906967,"threshold_uncertainty_score":0.999955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03311615634252496,"score_gpt":0.3320766060219594,"score_spread":0.2989604496794344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}