{"id":"W4312352271","doi":"10.1161/atvb.42.suppl_1.383","title":"Abstract 383: MLKL (Mixed Lineage Kinase Domain-like Protein) In The Splenic Microenvironment Restrains Hematopoietic Contributions To The Atherosclerotic Plaque","year":2022,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Montreal Heart Institute; Ottawa Heart Institute","funders":"","keywords":"Haematopoiesis; Biology; Progenitor cell; Bone marrow; Spleen; Cell biology; Myeloid; Endothelial stem cell; Stem cell; Necroptosis; Cancer research; Immunology; Molecular biology; Apoptosis; Programmed cell death; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008887245,0.0003261172,0.000172207,0.0001800809,0.0001852316,0.0003252215,0.0001584752,0.0002565863,0.002572811],"category_scores_gemma":[0.0001068726,0.0001030939,0.0001702981,0.0001351734,0.000238915,0.0002284213,0.0002171155,0.0006849934,0.0008253405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003223741,"about_ca_system_score_gemma":0.0002416149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003097718,"about_ca_topic_score_gemma":0.0003817031,"domain_scores_codex":[0.9998714,0.00001393661,0.00001122398,0.00003970876,0.00003640223,0.00002737816],"domain_scores_gemma":[0.9998946,0.00000901255,0.000039578,0.00000873573,0.00001329315,0.00003463996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001361992,0.00001234944,0.0001580218,0.00002661696,0.0000014262,0.00003133144,0.000006028391,0.00001666234,0.9988537,0.00005652032,0.00003728832,0.0006638602],"study_design_scores_gemma":[0.0000217686,0.0001323499,0.005958492,0.000005577599,0.00001175628,0.0002268086,0.00002790358,0.0004462909,0.9912655,0.00007703067,0.00182371,0.000002877392],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901633,0.001827613,0.004510334,0.0003470922,0.00006203046,0.00002105738,0.0008678013,0.0001888168,0.002011974],"genre_scores_gemma":[0.990049,0.0006626509,0.002292053,0.0001445555,0.00003062194,0.00003340754,0.0008475652,0.00004941647,0.005890736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002572811,"threshold_uncertainty_score":0.008606911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02024200738660523,"score_gpt":0.2559392966236924,"score_spread":0.2356972892370871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}