{"id":"W4312440945","doi":"10.2139/ssrn.4290052","title":"A Quinolin-8-Ol Sub-Millimolar Inhibitor of UGGT, the ER Glycoprotein Folding Quality Control Checkpoint","year":2022,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; University of British Columbia Hospital","funders":"","keywords":"Chemistry; Quality (philosophy); Folding (DSP implementation); Cancer research; Cell biology; Medicine; Biology; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002450006,0.0003978693,0.0005489026,0.0002278642,0.0002161799,0.0003797013,0.0005806966,0.000436334,0.00355778],"category_scores_gemma":[0.0002398293,0.0002003507,0.0002849094,0.0002711481,0.0002196233,0.0002793968,0.0001733164,0.001031153,0.0006979007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004220955,"about_ca_system_score_gemma":0.0003944009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009956312,"about_ca_topic_score_gemma":0.001933763,"domain_scores_codex":[0.9998624,0.00002336831,0.00001570686,0.00003355244,0.00002906398,0.00003586685],"domain_scores_gemma":[0.9998918,0.00002736126,0.0000194454,0.00001461499,0.00001352962,0.00003328107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00330061,0.0005084514,0.0003667768,0.0003558392,0.00008945179,0.0002740952,0.00004523669,0.001196763,0.9818476,0.0006812499,0.001972885,0.009361013],"study_design_scores_gemma":[0.001178799,0.004755496,0.005002825,0.0000353168,0.0001327232,0.0007888996,0.00008985271,0.006728586,0.9687585,0.0003882942,0.0120852,0.00005546974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9787633,0.005864467,0.004197121,0.0008639568,0.000379271,0.0001787111,0.002027142,0.0008525489,0.006873507],"genre_scores_gemma":[0.9889609,0.002532832,0.003047482,0.0002326345,0.00002741872,0.00006930737,0.001651341,0.00004031029,0.003437605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00355778,"threshold_uncertainty_score":0.01190192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01439336224379684,"score_gpt":0.281224852702012,"score_spread":0.2668314904582151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}