{"id":"W4312448520","doi":"10.2139/ssrn.4258954","title":"FTO Deubiquitinated by USP7&amp;nbsp;Influenced NEDD4 mRNA Stability Enhancing the Chemoresistance of Pancreatic Cancer to Gemcitabine by Promoting Cell Proliferation and Regulating PTEN/PI3K/AKT Pathway","year":2022,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Pancreas Centre (Canada)","funders":"","keywords":"PTEN; PI3K/AKT/mTOR pathway; Gemcitabine; Pancreatic cancer; Cancer research; Protein kinase B; Cell growth; Chemistry; Cancer; Cell biology; Signal transduction; Biology; Internal medicine; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009348363,0.0001886362,0.000190015,0.0001379508,0.0001399736,0.0002099441,0.0001482709,0.0001938463,0.001613811],"category_scores_gemma":[0.00008648373,0.0001186017,0.0001934019,0.0001218281,0.000225185,0.0001772957,0.0001194527,0.000374249,0.0002639878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002417723,"about_ca_system_score_gemma":0.0001850487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008125338,"about_ca_topic_score_gemma":0.001172038,"domain_scores_codex":[0.9999262,0.00000784166,0.000009476644,0.0000235085,0.00001406629,0.00001883919],"domain_scores_gemma":[0.9999595,0.000005461782,0.0000143971,0.0000060706,0.000003939275,0.00001064544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001897805,0.00001980618,0.0001457794,0.00002804479,0.000005616971,0.00004818645,0.000009880181,0.00006811769,0.997669,0.0001893306,0.00004625806,0.001580158],"study_design_scores_gemma":[0.000009332135,0.00008894775,0.001131378,0.000001770897,0.00001110915,0.00009049929,0.00000957724,0.0004578537,0.9962627,0.00003838078,0.001895304,0.000002903726],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952603,0.001044529,0.001579289,0.00008888452,0.00004845748,0.00001069877,0.0003382286,0.00007398565,0.001555715],"genre_scores_gemma":[0.9954651,0.0004055681,0.001018122,0.00003775502,0.000007408041,0.000010336,0.0003442887,0.00001826286,0.002693233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001613811,"threshold_uncertainty_score":0.00539881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00556118127029562,"score_gpt":0.2281731829644533,"score_spread":0.2226120016941577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}