{"id":"W4312462741","doi":"10.1136/ijgc-2022-esgo.685","title":"2022-RA-1310-ESGO Cost-effectiveness of unselected multigene germline and somatic genetic testing for epithelial ovarian cancer","year":2022,"lang":"en","type":"article","venue":"International Journal of Gynecological Cancer","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Genetics; Barts Health NHS Trust; Cancer Research UK; London School of Hygiene and Tropical Medicine; University of Washington; Queen Mary University of London; Univerzitetni Klinični Center Maribor","keywords":"Medicine; Genetic testing; Germline mutation; Germline; Oncology; PARP inhibitor; Breast cancer; Population; Ovarian cancer; BRCA mutation; Internal medicine; Cancer; Gynecology; Cost effectiveness; Genetics; Biology; Mutation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001215243,0.0003643916,0.0006013867,0.0005262513,0.0001231617,0.0005498331,0.000491356,0.0007116284,0.0109212],"category_scores_gemma":[0.002273367,0.0001708511,0.001065813,0.0003028974,0.0002382994,0.0004142537,0.0004238823,0.0004388171,0.001671508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001222175,"about_ca_system_score_gemma":0.000918748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003195585,"about_ca_topic_score_gemma":0.004299271,"domain_scores_codex":[0.999317,0.0004071658,0.0000196221,0.0000763887,0.00009894979,0.00008070087],"domain_scores_gemma":[0.9989402,0.0005022981,0.0001006627,0.00005589114,0.00005524346,0.0003457155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.1713917,0.007810782,0.2013787,0.0004409968,0.001624293,0.001593563,0.000105726,0.01653131,0.01757744,0.001893413,0.009128629,0.5705234],"study_design_scores_gemma":[0.01469416,0.0845627,0.8377447,0.0001602424,0.002122026,0.004577246,0.0002701844,0.03145224,0.006667139,0.001475616,0.0161478,0.0001260173],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841663,0.001771219,0.0007981285,0.001361414,0.00009132759,0.0001698198,0.001757256,0.000140616,0.009744034],"genre_scores_gemma":[0.9944957,0.0003034563,0.0007204892,0.0004892992,0.00005049504,0.0000516747,0.001124137,0.00001964626,0.002745153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0109212,"threshold_uncertainty_score":0.03653508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03085485211269914,"score_gpt":0.3402289262451403,"score_spread":0.3093740741324412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}