{"id":"W4312532856","doi":"10.2196/42032","title":"An Exploratory Trial of EPI-589 in Amyotrophic Lateral Sclerosis (EPIC-ALS): Protocol for a Multicenter, Open-Labeled, 24-Week, Single-Group Study","year":2022,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Amyotrophic lateral sclerosis; Medicine; Protocol (science); Multiple sclerosis; Exploratory research; Multicenter study; Clinical trial; EPIC; Physical medicine and rehabilitation; Psychology; Physical therapy; Internal medicine; Randomized controlled trial; Pathology; Disease; Alternative medicine; Psychiatry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02141607,0.006439167,0.005931632,0.001327408,0.003144274,0.002896653,0.00391898,0.006355874,0.02605513],"category_scores_gemma":[0.01470368,0.002667189,0.002925526,0.001694564,0.002748355,0.002684627,0.00185644,0.005659211,0.008332646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0030752,"about_ca_system_score_gemma":0.01321259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001291833,"about_ca_topic_score_gemma":0.0025345,"domain_scores_codex":[0.9908177,0.005738862,0.0006393524,0.0009992835,0.0008405908,0.0009642339],"domain_scores_gemma":[0.9916133,0.00139075,0.001693997,0.001205483,0.001580796,0.002515703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.9158269,0.04084713,0.001368832,0.003715809,0.0008795933,0.0004765443,0.0003566009,0.00235831,0.006668929,0.001601228,0.009756626,0.01614342],"study_design_scores_gemma":[0.8357024,0.1325974,0.003311147,0.0005483265,0.0004852453,0.0001584904,0.0001368887,0.001192632,0.001400374,0.001504091,0.02286922,0.00009372909],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.01408119,0.0003244587,0.001847004,0.0003078938,0.0002340927,0.9795718,0.001855878,0.0001127575,0.001664967],"genre_scores_gemma":[0.01205256,0.00031525,0.003179625,0.0004845286,0.0001291842,0.9819411,0.0008385224,0.0000130203,0.00104614],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.02605513,"threshold_uncertainty_score":0.1132603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.576953671828444,"score_gpt":0.5680640142704104,"score_spread":0.008889657558033615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}