{"id":"W4312574221","doi":"10.7554/elife.72498.sa1","title":"Decision letter: Empirical single-cell tracking and cell-fate simulation reveal dual roles of p53 in tumor suppression","year":2021,"lang":"en","type":"peer-review","venue":"","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; McGill University","funders":"","keywords":"Dual (grammatical number); Cell fate determination; Computer science; Dual role; Cell; Tracking (education); Single-cell analysis; Biology; Psychology; Chemistry; Art; Gene; Genetics; Literature","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00920639,0.0009902659,0.001252891,0.0009947066,0.001683674,0.003651411,0.003039421,0.006183175,0.176438],"category_scores_gemma":[0.08143968,0.0008674308,0.001402617,0.0008278835,0.0009573017,0.002093657,0.002441121,0.004470162,0.05041795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001854029,"about_ca_system_score_gemma":0.005138846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001323688,"about_ca_topic_score_gemma":0.002540371,"domain_scores_codex":[0.9933038,0.00209771,0.0008263692,0.0005638517,0.002681732,0.0005264181],"domain_scores_gemma":[0.9421967,0.02503598,0.00185664,0.00449825,0.02018787,0.006224549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0003157487,0.00008677353,0.000403505,0.000142873,0.00002235828,0.0002391112,0.00004385779,0.00131227,0.000586893,0.003802741,0.9696726,0.02337123],"study_design_scores_gemma":[0.0003642054,0.0001246453,0.0006840783,0.0002257274,0.0000275655,0.0001984118,0.00008426496,0.01755998,0.002612618,0.01330992,0.9647272,0.00008136361],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.01277542,0.00093882,0.07473332,0.3522415,0.4118265,0.00258044,0.02023249,0.01408984,0.1105817],"genre_scores_gemma":[0.1766714,0.003828134,0.1752014,0.1934839,0.1371175,0.005324167,0.01910516,0.01200106,0.2772674],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.176438,"threshold_uncertainty_score":0.5902441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02949757940900324,"score_gpt":0.3129193537829907,"score_spread":0.2834217743739875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}