{"id":"W4312580289","doi":"10.2139/ssrn.4237902","title":"Molnupiravir Plus Usual Care Versus Usual Care Alone as Early Treatment for Adults with COVID-19 at Increased Risk of Adverse Outcomes (PANORAMIC): Preliminary Analysis from the United Kingdom Randomised, Controlled Open-Label, Platform Adaptive Trial","year":2022,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute for Health and Care Research; Wellcome Trust","keywords":"Medicine; Adverse effect; Randomized controlled trial; Coronavirus disease 2019 (COVID-19); Emergency medicine; Confidence interval; Pediatrics; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002427978,0.001972937,0.005266382,0.0006248709,0.0004881409,0.001573525,0.001127999,0.002350156,0.008755256],"category_scores_gemma":[0.004048185,0.0009695783,0.004290063,0.0005469713,0.001289129,0.001822186,0.000832641,0.00345354,0.0009921191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001109508,"about_ca_system_score_gemma":0.001046658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002907303,"about_ca_topic_score_gemma":0.005951157,"domain_scores_codex":[0.998107,0.001130265,0.0001598094,0.0002843233,0.00009346384,0.0002250699],"domain_scores_gemma":[0.9985377,0.0005683413,0.0003609381,0.0001186182,0.00009325251,0.0003213251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9897682,0.001110967,0.0002915511,0.0007467867,0.001329086,0.0000167785,0.00003322752,0.00009831836,0.0003465157,0.00004694115,0.0002171361,0.005994585],"study_design_scores_gemma":[0.9698375,0.02648561,0.001765882,0.0001027129,0.001168061,0.00001755537,0.00002894597,0.0001733408,0.00007880993,0.0001077038,0.0002180102,0.00001576396],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9704536,0.01810357,0.0008252607,0.000919934,0.001249822,0.003658957,0.001432549,0.0001788046,0.003177509],"genre_scores_gemma":[0.9881402,0.003878322,0.001679486,0.0008511994,0.0005276187,0.002405143,0.0007132801,0.00002026178,0.001784494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008755256,"threshold_uncertainty_score":0.02928931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05523206237128343,"score_gpt":0.3563006056204013,"score_spread":0.3010685432491179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}