{"id":"W4312580289","doi":"10.2139/ssrn.4237902","title":"Molnupiravir Plus Usual Care Versus Usual Care Alone as Early Treatment for Adults with COVID-19 at Increased Risk of Adverse Outcomes (PANORAMIC): Preliminary Analysis from the United Kingdom Randomised, Controlled Open-Label, Platform Adaptive Trial","year":2022,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute for Health and Care Research; Wellcome Trust","keywords":"Medicine; Adverse effect; Randomized controlled trial; Coronavirus disease 2019 (COVID-19); Emergency medicine; Confidence interval; Pediatrics; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.00179213,0.0006020581,0.002025545,0.0007021677,0.001480389,0.00006621691,0.0008795442,0.0001801043,0.00006194257],"category_scores_gemma":[0.00122088,0.0003716345,0.0009300268,0.001219581,0.0002287238,0.0001908783,0.0003330926,0.001762227,0.000004245725],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.01235559,"about_ca_system_score_gemma":0.01602868,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.0703771,"about_ca_topic_score_gemma":0.02329713,"domain_scores_codex":[0.9939376,0.001008487,0.0009839418,0.0007226889,0.001463694,0.001883606],"domain_scores_gemma":[0.993189,0.004156167,0.001051366,0.0007089793,0.0006421637,0.0002523107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.947566,0.00078247,0.01824327,0.00002103609,0.02286317,0.0001476812,0.008509194,0.0006513155,0.0001098116,0.000251695,0.0000171653,0.0008371942],"study_design_scores_gemma":[0.8420261,0.06909332,0.0006804947,0.00003225585,0.01445566,0.00006850375,0.07004011,0.001941563,0.0002987837,0.0001913294,0.0008040194,0.0003679314],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869429,0.002438913,0.0004135565,0.0001973797,0.0001604058,0.008669182,0.001048086,0.00004290745,0.00008662495],"genre_scores_gemma":[0.9959495,0.0001167529,0.00007351026,0.001354717,0.000218173,0.001477784,0.0006446288,0.00008133155,0.00008356704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.10554,"threshold_uncertainty_score":0.9998736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05523206237128343,"score_gpt":0.3563006056204013,"score_spread":0.3010685432491179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}