{"id":"W4312615811","doi":"10.17925/usrpd.2022.7.2.44","title":"Tackling ‘People Remodelling’ in Corticosteroid-dependent Asthma with Type-2 Targeting Biologics and a Formal Corticosteroid Weaning Protocol","year":2022,"lang":"en","type":"article","venue":"touchREVIEWS in Respiratory & Pulmonary Diseases","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Lung Association; Insmed; Teva Pharmaceutical Industries; Regeneron Pharmaceuticals; Sanofi; GlaxoSmithKline; Genentech; AstraZeneca","keywords":"Corticosteroid; Medicine; Asthma; Dupilumab; Mepolizumab; Immunology; Intensive care medicine; Internal medicine; Eosinophil","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008953131,0.0006001187,0.001240842,0.0007103803,0.0006385128,0.001486889,0.001545243,0.002912194,0.004478004],"category_scores_gemma":[0.01010945,0.0002333849,0.001718831,0.0003572573,0.001169055,0.001549186,0.002179859,0.00378726,0.001220186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001358029,"about_ca_system_score_gemma":0.003968781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004535403,"about_ca_topic_score_gemma":0.001267078,"domain_scores_codex":[0.9960639,0.002139149,0.000822951,0.0002092616,0.0005526933,0.0002120371],"domain_scores_gemma":[0.9959924,0.002325663,0.0006647567,0.0002081722,0.000433083,0.0003759348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002662222,0.00157058,0.001247674,0.0430692,0.0007990734,0.0009142276,0.0005495498,0.001726775,0.005183109,0.02512496,0.03790136,0.8792512],"study_design_scores_gemma":[0.005046892,0.008522464,0.009902782,0.1000817,0.002754205,0.002985648,0.0008553347,0.002376223,0.007325848,0.04793677,0.8120204,0.0001917083],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"methods","genre_scores_codex":[0.03180397,0.7345207,0.05915935,0.08969291,0.01331983,0.01990839,0.000779641,0.000513696,0.05030157],"genre_scores_gemma":[0.1765799,0.5534797,0.1497894,0.06601954,0.01245624,0.02760829,0.001453353,0.0001650772,0.01244847],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.008953131,"threshold_uncertainty_score":0.04734921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02223817581527763,"score_gpt":0.2897002095188702,"score_spread":0.2674620337035926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}