{"id":"W4312648120","doi":"10.2139/ssrn.4236797","title":"Active Growth Signalling Promotes Senescence and Cancer Cell Sensitivity to CDK7 Inhibition","year":2022,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Senescence; Sensitivity (control systems); Signalling; Cell biology; Cell growth; Cancer; Signalling pathways; Chemistry; Signal transduction; Cancer research; Biology; Biochemistry; Genetics; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007213362,0.0001602469,0.0002208533,0.00008657086,0.0004014969,0.00001779179,0.00004309301,0.00002981572,0.0000746451],"category_scores_gemma":[0.00002564913,0.0001544105,0.00005659742,0.0002179344,0.00003908087,0.0002083959,0.00007164261,0.001418522,0.000002191264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002741945,"about_ca_system_score_gemma":0.00139987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003376369,"about_ca_topic_score_gemma":0.0005121705,"domain_scores_codex":[0.9979268,0.0001265356,0.0001665278,0.0002690939,0.0003487731,0.001162225],"domain_scores_gemma":[0.9994638,0.00004811042,0.0001258818,0.00008240407,0.0001390911,0.0001407162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00176442,0.0002075369,0.002515362,0.00004963326,0.0001951681,0.00009432163,0.002230715,0.0004573298,0.8631735,0.002041509,0.00001297438,0.1272576],"study_design_scores_gemma":[0.01114173,0.007611932,0.01248581,0.0005744339,0.0006169126,0.02491152,0.03870977,0.001349834,0.7842151,0.1135849,0.003065941,0.001732124],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9766598,0.004165668,0.01556926,0.002993861,0.0001010893,0.0003495649,0.00001564843,0.00004308435,0.0001019685],"genre_scores_gemma":[0.9971843,0.001315611,0.0002930056,0.0005465162,0.00029737,0.00004197872,0.000004056733,0.0000335797,0.0002835288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1255254,"threshold_uncertainty_score":0.7170092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007270155607277526,"score_gpt":0.2482749886445063,"score_spread":0.2410048330372288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}