{"id":"W4312648120","doi":"10.2139/ssrn.4236797","title":"Active Growth Signalling Promotes Senescence and Cancer Cell Sensitivity to CDK7 Inhibition","year":2022,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Senescence; Sensitivity (control systems); Signalling; Cell biology; Cell growth; Cancer; Signalling pathways; Chemistry; Signal transduction; Cancer research; Biology; Biochemistry; Genetics; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001862284,0.0002869744,0.0003374048,0.000338848,0.0002733542,0.000737896,0.0002410528,0.0003498229,0.005563181],"category_scores_gemma":[0.0002745012,0.0001508548,0.0003099875,0.0002513214,0.0002580994,0.0003032222,0.0003000091,0.0009989595,0.001787466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005077128,"about_ca_system_score_gemma":0.0004696894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007936198,"about_ca_topic_score_gemma":0.001645198,"domain_scores_codex":[0.9997867,0.0000333127,0.00001820229,0.00002881244,0.00006024331,0.00007277015],"domain_scores_gemma":[0.9998327,0.00003216712,0.00003356361,0.00002557874,0.00002622796,0.00004970182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001275891,0.0002810991,0.0008666286,0.0001262836,0.00003853455,0.0001345831,0.00004054711,0.0002400132,0.9859994,0.0008361027,0.0009510753,0.00920987],"study_design_scores_gemma":[0.0001073814,0.001367152,0.0102477,0.00001843432,0.00003891467,0.0005318099,0.0001214452,0.001062655,0.9734697,0.0003114665,0.01270885,0.00001467386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830261,0.004774539,0.0007629396,0.0004236708,0.0001480904,0.00003466211,0.0008833592,0.0001844135,0.009762164],"genre_scores_gemma":[0.9926035,0.001337596,0.0002977252,0.00008224451,0.0000214974,0.00002186361,0.0008513066,0.00002445054,0.00475977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005563181,"threshold_uncertainty_score":0.01861066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007270155607277526,"score_gpt":0.2482749886445063,"score_spread":0.2410048330372288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}