{"id":"W4312709268","doi":"10.1007/978-3-030-62345-6_5222","title":"Li-Fraumeni Syndrome","year":2022,"lang":"en","type":"book-chapter","venue":"Encyclopedia of pathology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Li–Fraumeni syndrome; Biology; Genetics; Mutation; Germline mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002298248,0.0004639932,0.00118976,0.0004802157,0.00006007433,0.000002743061,0.0002635424,0.0007705415,0.01528542],"category_scores_gemma":[0.0001014272,0.0005032455,0.0004457209,0.00007650368,0.0002704791,0.00003245443,0.0003203886,0.001383515,0.0004281204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000244802,"about_ca_system_score_gemma":0.0005036028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001561136,"about_ca_topic_score_gemma":0.000009549903,"domain_scores_codex":[0.9976169,0.00005157595,0.0007184788,0.0007097264,0.0005167974,0.0003864605],"domain_scores_gemma":[0.9981543,0.00008138727,0.0004599893,0.001018694,0.0001021853,0.0001834889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00163667,0.001140132,0.0007133025,0.0030798,0.003102475,0.3573097,0.003699129,0.0001166364,0.009426045,0.3772734,0.1503684,0.09213423],"study_design_scores_gemma":[0.001129954,0.001493337,0.0003241945,0.0001673397,0.0005881595,0.01129563,0.00001393665,0.000002219929,0.00005342238,0.003197542,0.981326,0.0004082487],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.003237083,0.005368853,0.00006645449,0.000394874,0.001976646,0.0007424728,0.0002291576,0.0001268823,0.9878576],"genre_scores_gemma":[0.006470618,0.01050718,0.00137839,0.000627255,0.0004476815,0.0001156637,0.0007025527,0.0003320398,0.9794186],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.8309576,"threshold_uncertainty_score":0.9997419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01143157670105244,"score_gpt":0.2371819089208089,"score_spread":0.2257503322197564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}