{"id":"W4312709268","doi":"10.1007/978-3-030-62345-6_5222","title":"Li-Fraumeni Syndrome","year":2022,"lang":"en","type":"book-chapter","venue":"Encyclopedia of pathology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Li–Fraumeni syndrome; Biology; Genetics; Mutation; Germline mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008782677,0.0005995076,0.0002957712,0.0010176,0.0003632616,0.0006025249,0.0003358664,0.0005994702,0.04379141],"category_scores_gemma":[0.0002455288,0.0001468988,0.0001834453,0.0006909608,0.0003199699,0.0006379204,0.0005547717,0.0008776907,0.01632457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004102552,"about_ca_system_score_gemma":0.0003457458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008127952,"about_ca_topic_score_gemma":0.002576636,"domain_scores_codex":[0.9999501,0.000005380281,0.000002452209,0.000008924371,0.00002551087,0.00000760292],"domain_scores_gemma":[0.9999626,0.00001697354,0.000003111858,0.000003418447,0.000006259935,0.000007591755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002955612,0.00002739635,0.0003462012,0.0002348385,0.00001014534,0.005117049,0.0002168843,0.0002940418,0.003203266,0.06532608,0.4407745,0.4844199],"study_design_scores_gemma":[0.000002747301,0.000007614331,0.0002435028,0.00007986004,0.000002957812,0.00740419,0.00002498748,0.00004344802,0.0003146401,0.005232764,0.9866396,0.000003712011],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.003150692,0.1122418,0.006081764,0.004206556,0.004131878,0.0000406752,0.000427759,0.0004595443,0.8692593],"genre_scores_gemma":[0.01217035,0.04892024,0.003446055,0.001853814,0.0008448727,0.00004023165,0.0003717552,0.00009469027,0.9322581],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.04379141,"threshold_uncertainty_score":0.1464969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01143157670105244,"score_gpt":0.2371819089208089,"score_spread":0.2257503322197564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}