{"id":"W4312783363","doi":"10.1515/biol-2022-0449","title":"Early cancer detection by a targeted methylation assay of circulating tumor DNA in plasma","year":2022,"lang":"en","type":"article","venue":"Open Life Sciences","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Sinai Hospital; University Health Network; University of Toronto","funders":"","keywords":"Biology; DNA methylation; Cancer; DNA; Methylation; Circulating tumor DNA; Molecular biology; Cancer research; Cancer detection; Genetics; Computational biology; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003509923,0.0004577216,0.0003999616,0.0007532268,0.0002033579,0.0003862239,0.000362587,0.0007696031,0.001148108],"category_scores_gemma":[0.0009448976,0.0003237928,0.0002315173,0.0003612626,0.0002090499,0.0002374369,0.0002390114,0.0007943344,0.0005268802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002307369,"about_ca_system_score_gemma":0.0003225472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007572565,"about_ca_topic_score_gemma":0.001168144,"domain_scores_codex":[0.9996326,0.0000769647,0.000009610066,0.0001182732,0.0001134968,0.00004907529],"domain_scores_gemma":[0.9997519,0.00009848829,0.00004361398,0.00002602056,0.00004541793,0.00003461986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009113748,0.00009479858,0.04207292,0.00009522091,0.00006584032,0.0002678709,0.0001233431,0.000428732,0.9204816,0.0002558883,0.0007350755,0.03446733],"study_design_scores_gemma":[0.00009266415,0.001377766,0.1015729,0.00003717478,0.0001964632,0.00375717,0.0001321046,0.01871887,0.8676846,0.001140243,0.005250836,0.00003914867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8928276,0.00457115,0.09398212,0.0007842714,0.0001918848,0.0001609643,0.001948312,0.001350423,0.004183333],"genre_scores_gemma":[0.9718764,0.0006894714,0.02341505,0.0002984092,0.00008091063,0.0001067457,0.0005358789,0.00004708227,0.002950143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001148108,"threshold_uncertainty_score":0.003840804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01760023603556195,"score_gpt":0.2834353747247459,"score_spread":0.265835138689184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}