{"id":"W4312844936","doi":"10.2139/ssrn.4229510","title":"<i>Pten</i> Regulates Endocytic Trafficking of Cell Adhesion and Signaling Molecules to Pattern the Retina","year":2022,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health; Sunnybrook Health Science Centre; Stem Cell Network; University of Ottawa; University of Lethbridge; McGill University; University of Calgary; Montreal Clinical Research Institute; Sunnybrook Hospital","funders":"","keywords":"Endocytic cycle; Cell biology; PTEN; Retina; Cell adhesion; Cell adhesion molecule; Cell signaling; Signal transduction; Chemistry; Cell; Biology; Endocytosis; Neuroscience; PI3K/AKT/mTOR pathway; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002798263,0.0008162148,0.0004164921,0.0009218999,0.0004893755,0.001391677,0.0008529291,0.0007973497,0.00699608],"category_scores_gemma":[0.0003164264,0.0005122542,0.0003763466,0.0004654033,0.001196283,0.0008097313,0.0005426358,0.001920621,0.002925789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001150515,"about_ca_system_score_gemma":0.0008547063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003448948,"about_ca_topic_score_gemma":0.004289615,"domain_scores_codex":[0.9995616,0.00004209818,0.00002703926,0.0001019931,0.0001262599,0.0001408902],"domain_scores_gemma":[0.9996661,0.00002818924,0.00010248,0.0000335998,0.00002746597,0.0001422501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002411888,0.00004842809,0.0002479749,0.00005381959,0.00001025875,0.0001817061,0.00002496385,0.0003952094,0.9927537,0.002730086,0.0006644276,0.002648199],"study_design_scores_gemma":[0.00007534883,0.0001188584,0.003824943,0.0000175397,0.00004526541,0.0004402922,0.000126688,0.004527585,0.9785566,0.0005449212,0.01170254,0.00001947223],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9404499,0.002230088,0.02071257,0.001732288,0.0004170505,0.00009778924,0.003300537,0.002089827,0.02896992],"genre_scores_gemma":[0.979115,0.0006702135,0.003582085,0.0002271091,0.00003313546,0.00004622418,0.0007361504,0.0004513738,0.01513864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00699608,"threshold_uncertainty_score":0.02340418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004793518828584419,"score_gpt":0.1930757348583139,"score_spread":0.1882822160297295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}