{"id":"W4312914915","doi":"10.2139/ssrn.4283169","title":"A Target Discovery Pipeline Identified ILT3 as a Target for Immunotherapy of Multiple Myeloma","year":2022,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Occupational Cancer Research Centre","funders":"","keywords":"Multiple myeloma; Immunotherapy; Pipeline (software); Medicine; Computational biology; Computer science; Immunology; Biology; Immune system; Programming language","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005449257,0.0007905897,0.000915438,0.0006779129,0.0004833477,0.001551752,0.000491347,0.0006990643,0.00599963],"category_scores_gemma":[0.0005703961,0.0002323707,0.001004579,0.0009101952,0.0001501702,0.0004661081,0.0006421265,0.001102082,0.003190693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008784437,"about_ca_system_score_gemma":0.0016215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009738203,"about_ca_topic_score_gemma":0.001855585,"domain_scores_codex":[0.9997321,0.00002394083,0.00001258077,0.00006380004,0.0001201747,0.00004741488],"domain_scores_gemma":[0.999845,0.0000377061,0.00002348867,0.00001371036,0.0000483693,0.00003161934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002053699,0.0003358142,0.008029476,0.002102068,0.0004444483,0.001095814,0.0001230631,0.008099949,0.6639532,0.004475489,0.03572961,0.2735573],"study_design_scores_gemma":[0.0008077247,0.002368609,0.01481385,0.000350546,0.001772289,0.002515159,0.0001696941,0.06517908,0.594717,0.01084676,0.3063295,0.0001297677],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.575099,0.06223872,0.1442661,0.009333971,0.001651647,0.001909882,0.09644,0.02207336,0.08698737],"genre_scores_gemma":[0.7197653,0.02600035,0.1176047,0.003479823,0.0002941559,0.000691348,0.1009142,0.0007870363,0.03046317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00599963,"threshold_uncertainty_score":0.02007073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006800131982348879,"score_gpt":0.2340199110674359,"score_spread":0.227219779085087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}