{"id":"W4312919370","doi":"10.47611/jsr.v11i1.1534","title":"Current Sickle Cell Disease Gene Therapy Treatments: Literature Review","year":2022,"lang":"en","type":"article","venue":"Journal of Student Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McMaster University","funders":"","keywords":"Genetic enhancement; CRISPR; Genome editing; Disease; Viral vector; Fetal hemoglobin; Cas9; Medicine; Gene; Haematopoiesis; Stem cell; Clinical trial; Bioinformatics; Mutation; Immunology; Biology; Fetus; Internal medicine; Genetics; Pregnancy; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008999608,0.0005538411,0.001158243,0.003803052,0.0003423331,0.001144796,0.0008520542,0.0008301684,0.005599566],"category_scores_gemma":[0.002106474,0.0002463131,0.0006955867,0.003860445,0.0003923063,0.001148493,0.0004839113,0.0007889839,0.001588384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005412574,"about_ca_system_score_gemma":0.002166593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001016222,"about_ca_topic_score_gemma":0.001689538,"domain_scores_codex":[0.999597,0.0000561228,0.0001143079,0.00005999037,0.0001519334,0.00002069332],"domain_scores_gemma":[0.9983208,0.0009264806,0.0002729034,0.00003681895,0.0003763299,0.00006669963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007548823,0.00006321604,0.0002631632,0.0641569,0.0001262085,0.0002266737,0.0001382286,0.0001764616,0.001314466,0.001760897,0.03926821,0.8924301],"study_design_scores_gemma":[0.00001776419,0.0001297338,0.001484276,0.03587441,0.0007852314,0.002284335,0.0001665445,0.00009854551,0.001298788,0.001473048,0.9563592,0.00002811023],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002615558,0.9973537,0.0002041197,0.00048965,0.0002359681,0.00001182673,0.00006776324,0.00001558966,0.001359902],"genre_scores_gemma":[0.0009305644,0.9980078,0.0002951226,0.0002716672,0.0001248948,0.00001038417,0.00007994285,0.000002954563,0.0002766948],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005599566,"threshold_uncertainty_score":0.01873237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04990678952834119,"score_gpt":0.4636350668056981,"score_spread":0.4137282772773569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}