{"id":"W4312919370","doi":"10.47611/jsr.v11i1.1534","title":"Current Sickle Cell Disease Gene Therapy Treatments: Literature Review","year":2022,"lang":"en","type":"article","venue":"Journal of Student Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McMaster University","funders":"","keywords":"Genetic enhancement; CRISPR; Genome editing; Disease; Viral vector; Fetal hemoglobin; Cas9; Medicine; Gene; Haematopoiesis; Stem cell; Clinical trial; Bioinformatics; Mutation; Immunology; Biology; Fetus; Internal medicine; Genetics; Pregnancy; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007774914,0.00009726526,0.0001396097,0.00009525456,0.0001404528,0.00003345429,0.0003742891,0.0000171135,0.00009284534],"category_scores_gemma":[0.00002233408,0.00007548064,0.0001560027,0.0002133556,0.00002037373,0.000003284669,0.0002426163,0.000378881,0.000002717559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005258924,"about_ca_system_score_gemma":0.0001238048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":5.78658e-7,"about_ca_topic_score_gemma":1.741086e-7,"domain_scores_codex":[0.9984329,0.0001930966,0.0002390503,0.0001539672,0.0007575824,0.0002233809],"domain_scores_gemma":[0.9992635,0.0000131854,0.00007053553,0.0002396197,0.0002488257,0.0001643327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009172119,0.004803164,0.02082255,0.001185208,0.0005779921,0.0008055631,0.0008709247,0.001981538,0.7421685,0.00002205459,0.1643817,0.06146364],"study_design_scores_gemma":[0.002547199,0.002860771,0.02947836,0.000611413,0.00006797358,0.0001338791,0.0002247692,0.00001203354,0.05465357,0.00004269994,0.9090818,0.0002855231],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.4037133,0.5953719,0.00007530492,0.0003526707,0.0001811502,0.0002041984,0.00001486079,0.000001477123,0.00008519486],"genre_scores_gemma":[0.536848,0.4619311,0.00006857406,0.0001103842,0.0003805839,0.00003751191,0.00003168936,0.00001507359,0.0005770738],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.7447001,"threshold_uncertainty_score":0.3078011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04990678952834119,"score_gpt":0.4636350668056981,"score_spread":0.4137282772773569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}