{"id":"W4312931921","doi":"10.1071/rd22203","title":"Metabolism-epigenetic interactions on in vitro produced embryos","year":2022,"lang":"en","type":"review","venue":"Reproduction Fertility and Development","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministère de l'Agriculture, des Pêcheries et de l'Alimentation","funders":"","keywords":"Epigenetics; Epigenome; Biology; Reprogramming; DNA methylation; Histone; Metabolome; Chromatin; Cell biology; Epigenetic regulation of neurogenesis; Epigenomics; Epigenesis; Crosstalk; Genetics; Chromatin remodeling; Metabolomics; Gene expression; Bioinformatics; Cell; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008280692,0.000351208,0.0006221416,0.0002404558,0.0002047295,0.00003506311,0.0001400597,0.0001605417,0.00006994696],"category_scores_gemma":[0.0003002771,0.0003338825,0.0001283095,0.0002492427,0.00003978601,0.00000527102,0.0001950872,0.0003421277,0.00001688669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001262356,"about_ca_system_score_gemma":0.0003741139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001183779,"about_ca_topic_score_gemma":0.00001386393,"domain_scores_codex":[0.9971694,0.0003294435,0.0007093174,0.001320279,0.0002231027,0.0002484343],"domain_scores_gemma":[0.9988675,0.00002800796,0.0002299233,0.0007477046,0.00004649588,0.00008044559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001215601,0.0001897202,0.000008366422,0.0008445138,0.00007171864,0.000001247522,0.00009074589,0.00001883669,0.002135894,0.000002395476,0.00002450591,0.9964905],"study_design_scores_gemma":[0.0001417154,0.00004415226,0.001028967,0.0001392123,0.00004956897,0.000005131261,0.00002543972,0.000001127708,0.03376099,0.000015087,0.9644681,0.0003205583],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01118723,0.9867326,0.00005908558,0.00004583932,0.000785288,0.000876051,0.00001372028,0.00001958105,0.0002806046],"genre_scores_gemma":[0.003781527,0.9932114,0.0005670133,0.00002096459,0.0001887213,0.0005096711,0.0007805168,0.00004191156,0.0008982841],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9961699,"threshold_uncertainty_score":0.9999113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06813921864202055,"score_gpt":0.3304783055703189,"score_spread":0.2623390869282983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}