{"id":"W4312948438","doi":"10.18103/mra.v10i9.3020","title":"Eradication of leukemia stem cells by inhibitors of DNA methyltransferase, EZH2 and G9a histone methyltransferases","year":2022,"lang":"en","type":"article","venue":"Medical Research Archives","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"EZH2; Methyltransferase; DNA methylation; Epigenetics; Gene silencing; Histone methyltransferase; Biology; Methylation; Cancer research; DNA methyltransferase; Epigenetic therapy; Histone methylation; Molecular biology; Cancer epigenetics; DNMT1; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001756449,0.0001194942,0.0002371772,0.0001959351,0.0001702236,0.000006770865,0.0003188647,0.0000845089,0.0001249786],"category_scores_gemma":[0.0002631563,0.0001144173,0.00008595476,0.0002358071,0.0007766469,0.0000040339,0.000197292,0.0003686015,4.967303e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002546989,"about_ca_system_score_gemma":0.0004131404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001461956,"about_ca_topic_score_gemma":0.00001840598,"domain_scores_codex":[0.9967575,0.001028258,0.0004259195,0.0003689672,0.00112307,0.0002962797],"domain_scores_gemma":[0.9988016,0.0005196863,0.00006521872,0.0002871382,0.00006954138,0.0002567486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001606783,0.0001271138,0.0005016266,0.00007726086,0.00005021385,0.000002054537,0.000358094,0.00002759958,0.925097,0.0001502951,0.0005816229,0.07286639],"study_design_scores_gemma":[0.0005390467,0.0009621917,0.0004158316,0.00002063581,0.00001332044,0.000001398595,0.00025083,0.0001952077,0.9713236,0.0005051412,0.02567133,0.0001014566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9791964,0.01359842,0.005788718,0.000385817,0.00006180479,0.0002650457,0.0001533608,0.000005026849,0.0005454042],"genre_scores_gemma":[0.9913549,0.007617891,0.0004055968,0.00002628659,0.00005496922,0.000059582,0.0001361504,0.00002026115,0.0003243308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07276493,"threshold_uncertainty_score":0.4665801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01976401940820373,"score_gpt":0.3232654723576229,"score_spread":0.3035014529494192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}