{"id":"W4313033973","doi":"10.1016/bs.mcb.2022.09.011","title":"Methods for detection of mitochondrial reactive oxygen species in senescent cells","year":2022,"lang":"en","type":"article","venue":"Methods in cell biology","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Centre National pour la Recherche Scientifique et Technique; Centre National de la Recherche Scientifique; Hearing Industry Research Consortium; Providence Health Care; Cancer Research Institute","keywords":"Biology; Senescence; Carcinogenesis; Cell biology; Mitochondrial ROS; Reactive oxygen species; Proinflammatory cytokine; DNA damage; Genome instability; Cell cycle; Cell cycle checkpoint; Context (archaeology); Cell; Inflammation; Cancer; Immunology; Genetics; DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002362103,0.0001871577,0.0006926026,0.000498512,0.0000699308,0.000002998858,0.0001703461,0.0001776344,0.000129179],"category_scores_gemma":[0.0005140954,0.000177607,0.0001567066,0.0005679168,0.0001322934,0.00002624569,0.0001313853,0.0004329353,0.000001118639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002943381,"about_ca_system_score_gemma":0.00012079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003112061,"about_ca_topic_score_gemma":0.00005643459,"domain_scores_codex":[0.9959699,0.002460354,0.0006035334,0.0004948659,0.00009229562,0.0003790572],"domain_scores_gemma":[0.9975356,0.001780244,0.0002227579,0.000330394,0.00006831524,0.0000626204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001103952,0.0002421267,0.001408106,0.00008452856,0.00001686705,0.000006168114,0.0008177917,0.0000325937,0.8779045,0.0000545471,0.00002129077,0.1183075],"study_design_scores_gemma":[0.001863685,0.0007786242,0.00287533,0.00001216743,0.00003268485,0.00001086949,0.001188918,0.0006850439,0.9197702,0.0009786489,0.0716485,0.0001552744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.4106966,0.001649316,0.5785041,0.0002849108,0.004756528,0.002121107,0.00006748938,0.00005387678,0.001866073],"genre_scores_gemma":[0.1308775,0.000138452,0.8677107,0.0001669913,0.0002035078,0.0002503412,0.00003457849,0.00002832568,0.0005896203],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.2892066,"threshold_uncertainty_score":0.7242603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05226195424441715,"score_gpt":0.4059569008025878,"score_spread":0.3536949465581706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}