{"id":"W4313127679","doi":"10.1136/ijgc-2022-esgo.878","title":"2022-RA-945-ESGO Antitumour activity of dostarlimab by PD-L1 and tumour mutation burden in patients with mismatch repair deficient and proficient tumours in the GARNET trial","year":2022,"lang":"en","type":"article","venue":"International Journal of Gynecological Cancer","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; Centre Hospitalier de l’Université de Montréal; Kelowna General Hospital","funders":"","keywords":"Medicine; Discontinuation; Oncology; Internal medicine; Cancer; Chemotherapy; DNA mismatch repair","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001081147,0.0007684591,0.001615838,0.0002528095,0.0002103357,0.001129477,0.0004377578,0.0009770092,0.002594185],"category_scores_gemma":[0.0005885684,0.0003308872,0.001084304,0.0003266095,0.0006155305,0.0007733455,0.0003641682,0.002051925,0.0006023139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008218994,"about_ca_system_score_gemma":0.0007175062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004616391,"about_ca_topic_score_gemma":0.00185486,"domain_scores_codex":[0.9995239,0.0002228458,0.00002124037,0.00006370401,0.0000418643,0.0001266001],"domain_scores_gemma":[0.9996912,0.0000588205,0.00005198644,0.00003386104,0.00001688488,0.0001472385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8410335,0.003673548,0.01759758,0.0006967722,0.002825825,0.0002725408,0.0001695121,0.00241031,0.02416657,0.0008583131,0.00354002,0.1027555],"study_design_scores_gemma":[0.5546061,0.3046025,0.1009395,0.0001985321,0.004584512,0.0008658714,0.0001998884,0.003455247,0.01037703,0.00173742,0.01831477,0.0001186527],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940553,0.002524244,0.0001219946,0.0005519224,0.00009105101,0.0001248315,0.0004106379,0.00005206864,0.002067903],"genre_scores_gemma":[0.9951897,0.0008104425,0.0002059249,0.0005627308,0.00007708702,0.0001501618,0.0009902669,0.00001616701,0.001997471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002594185,"threshold_uncertainty_score":0.008678377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01114241010865242,"score_gpt":0.2752725663059558,"score_spread":0.2641301561973034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}