{"id":"W4313148439","doi":"10.1016/j.exphem.2022.07.270","title":"3214 – DNMT3A R882 MUTATION IN HUMAN HAEMATOPOIETIC STEM CELLS ALTERS DIFFERENTIATION TOWARDS NEUTROPHILS AND MONOCYTES","year":2022,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Research Canada","funders":"","keywords":"Haematopoiesis; Biology; Myeloid; Stem cell; Monocyte; Mutation; CD33; Phenotype; Somatic cell; Immunology; Genetics; Cancer research; CD34; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001499937,0.0001838075,0.0004321007,0.0003078996,0.0001966555,0.00001886897,0.0001209153,0.00007779897,0.0003615989],"category_scores_gemma":[0.00000443181,0.0001887469,0.000058417,0.0002003632,0.0001269454,0.00009050909,0.0002889274,0.0003283865,0.00001667069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006219719,"about_ca_system_score_gemma":0.00007202802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001332416,"about_ca_topic_score_gemma":0.000004799414,"domain_scores_codex":[0.9983422,0.0002085855,0.0003676788,0.0004158478,0.0003050874,0.0003606279],"domain_scores_gemma":[0.999468,0.00005520062,0.00009525509,0.000239984,0.00002120167,0.0001203522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009209794,0.001660995,0.01148378,0.0004030489,0.0001501705,0.002284061,0.01099762,0.00008427258,0.9393545,0.02850694,0.00196361,0.002190052],"study_design_scores_gemma":[0.003714935,0.000967679,0.002996831,0.00002740654,0.0000206377,0.001262454,0.007473876,0.002233905,0.9807503,0.0002193871,0.0001380673,0.0001944702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952671,0.002578979,0.00004698187,0.0007199437,0.0001760963,0.0006917893,0.000006492956,0.0000571172,0.0004555154],"genre_scores_gemma":[0.9988092,0.00001958393,0.0001593375,0.0003271436,0.00002899237,0.0003351496,0.00006531429,0.00003482719,0.0002204383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04139589,"threshold_uncertainty_score":0.7696875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02506508115797824,"score_gpt":0.3181022654254217,"score_spread":0.2930371842674435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}