{"id":"W4313148439","doi":"10.1016/j.exphem.2022.07.270","title":"3214 – DNMT3A R882 MUTATION IN HUMAN HAEMATOPOIETIC STEM CELLS ALTERS DIFFERENTIATION TOWARDS NEUTROPHILS AND MONOCYTES","year":2022,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Research Canada","funders":"","keywords":"Haematopoiesis; Biology; Myeloid; Stem cell; Monocyte; Mutation; CD33; Phenotype; Somatic cell; Immunology; Genetics; Cancer research; CD34; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001063042,0.0002228815,0.0001878148,0.0001893511,0.0001443823,0.0001764695,0.0002268186,0.0004935713,0.006553571],"category_scores_gemma":[0.0001949558,0.0001446522,0.0002703969,0.0001689454,0.0002513444,0.00008609608,0.0001707251,0.0003781706,0.000981343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002023286,"about_ca_system_score_gemma":0.0002350836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00134011,"about_ca_topic_score_gemma":0.001271263,"domain_scores_codex":[0.999827,0.00004282403,0.00002664526,0.00003353257,0.00004121832,0.00002877892],"domain_scores_gemma":[0.999917,0.00002140705,0.00002336056,0.0000139052,0.000005722662,0.0000185106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003365645,0.00005552736,0.0009005253,0.00003029495,0.0000260551,0.000450552,0.00002854368,0.0002066217,0.9950352,0.0002243201,0.0001781,0.002527733],"study_design_scores_gemma":[0.0003116516,0.001209552,0.0299396,0.00003137536,0.0001390767,0.005171427,0.0001879748,0.003770783,0.9461852,0.0003486287,0.01267906,0.00002580391],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967191,0.0002466602,0.0006465181,0.0001014861,0.00004425816,0.00003248407,0.0006334887,0.0000526328,0.001523454],"genre_scores_gemma":[0.997319,0.0001242808,0.0003872628,0.00005885438,0.000005375595,0.00001844133,0.0004298582,0.00002212116,0.001634746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006553571,"threshold_uncertainty_score":0.02192384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02506508115797824,"score_gpt":0.3181022654254217,"score_spread":0.2930371842674435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}