{"id":"W4313185645","doi":"10.2139/ssrn.4297913","title":"Protease-Deleted Adenovirus as an Alternative for Replication-Competent Adenovirus Vector","year":2022,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"National Research Council Canada","funders":"","keywords":"Virology; Replication (statistics); Vector (molecular biology); Viral vector; Adenoviridae; Protease; Biology; Viral replication; Virus; Genetics; Genetic enhancement; Gene; Recombinant DNA; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006849343,0.0006463893,0.0005479131,0.0007792413,0.0003287516,0.0009455329,0.0007061717,0.0005809643,0.002135441],"category_scores_gemma":[0.0002793129,0.0003238021,0.0004553572,0.0005162413,0.0003194036,0.0006745122,0.0004107064,0.001391463,0.001582857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006280997,"about_ca_system_score_gemma":0.0006198058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004935575,"about_ca_topic_score_gemma":0.0006158234,"domain_scores_codex":[0.9994484,0.00008536236,0.00008198131,0.0001397843,0.0001780337,0.00006655633],"domain_scores_gemma":[0.999744,0.00004604295,0.00004039342,0.00006715739,0.00004497243,0.00005742283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002427944,0.00005441413,0.00009851688,0.00007734655,0.000008200713,0.00005968055,0.000024907,0.00005780627,0.9924461,0.001862836,0.0001677739,0.004899748],"study_design_scores_gemma":[0.00005326735,0.000267494,0.0004535612,0.00001040333,0.00005207333,0.0007098803,0.00002304657,0.0009422965,0.9761238,0.0002115668,0.02113194,0.00002057898],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.807179,0.008917049,0.164005,0.000704415,0.001580905,0.0005178449,0.003163082,0.002154606,0.01177807],"genre_scores_gemma":[0.8190567,0.003485438,0.1421464,0.0001564004,0.0001003802,0.0001914145,0.006484611,0.000438594,0.0279402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002135441,"threshold_uncertainty_score":0.007143736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01860798195024143,"score_gpt":0.3128344342618798,"score_spread":0.2942264523116384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}