{"id":"W4313217420","doi":"10.1021/acschembio.2c00638","title":"Attenuation of Polysialic Acid Biosynthesis in Cells by the Small Molecule Inhibitor 8-Keto-sialic acid","year":2022,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of British Columbia; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Glycomics Network; Canadian Institutes of Health Research","keywords":"Polysialic acid; Sialic acid; Biochemistry; Chemistry; N-Acetylneuraminic acid; Glycan; Cell; Sialyltransferase; Secretion; Glycoprotein; Neural cell adhesion molecule; Cell adhesion","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001381954,0.0003480299,0.0002225027,0.0001024729,0.00009977064,0.000237796,0.0001782805,0.0001774517,0.0007094601],"category_scores_gemma":[0.00008907286,0.0001070288,0.0002025904,0.0001004788,0.0001447748,0.0001357458,0.0001396389,0.0004580395,0.0003477008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002192938,"about_ca_system_score_gemma":0.0002857538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006117387,"about_ca_topic_score_gemma":0.000894279,"domain_scores_codex":[0.9998987,0.00001726251,0.00001272711,0.00001806831,0.00003074796,0.0000224613],"domain_scores_gemma":[0.9999318,0.00001522266,0.00001918869,0.00001037573,0.000008104194,0.00001523422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006903725,0.0000191396,0.00004450146,0.0000170946,0.000002922358,0.00001376296,0.000006020304,0.00006042285,0.9985892,0.00007460372,0.00002152531,0.001081645],"study_design_scores_gemma":[0.000006696038,0.0002181451,0.0003173781,0.000001749614,0.000004544025,0.00003437553,0.000003412775,0.0003823577,0.997426,0.000009261072,0.001594548,0.000001655195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853704,0.003163885,0.007455542,0.0001228936,0.00007095352,0.00007820742,0.00042638,0.0001630121,0.003148736],"genre_scores_gemma":[0.984673,0.002657538,0.007776065,0.0000702022,0.00001614172,0.00007591739,0.0004921191,0.00003095858,0.004207978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007094601,"threshold_uncertainty_score":0.002373457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01228170968955388,"score_gpt":0.2496644453214344,"score_spread":0.2373827356318805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}