{"id":"W4313222766","doi":"10.1007/s43678-022-00432-8","title":"Intravenous tenecteplase compared with alteplase for acute ischemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial","year":2022,"lang":"en","type":"article","venue":"Canadian Journal of Emergency Medicine","topic":"Acute Ischemic Stroke Management","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"Tenecteplase; Medicine; Stroke (engine); Fibrinolytic agent; Open label; Ischaemic stroke; Ischemic stroke; Randomized controlled trial; Thrombolysis; Tissue plasminogen activator; Internal medicine; Ischemia; Myocardial infarction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001913197,0.002237684,0.003713316,0.0003888212,0.00092041,0.001605785,0.001046336,0.001836629,0.006294156],"category_scores_gemma":[0.004040659,0.000637635,0.00257503,0.0008302761,0.001578829,0.001063767,0.0005904973,0.003335965,0.0006815139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003895093,"about_ca_system_score_gemma":0.005712889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.04787664,"about_ca_topic_score_gemma":0.08898303,"domain_scores_codex":[0.9986073,0.0006753342,0.00008813484,0.0002170323,0.000160795,0.00025135],"domain_scores_gemma":[0.9984302,0.0004317216,0.0004033012,0.0001165728,0.000192657,0.000425588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9870522,0.001509035,0.0004103582,0.000749908,0.001843048,0.00002906448,0.00005175091,0.0001583114,0.0003996985,0.0001953187,0.0010147,0.00658666],"study_design_scores_gemma":[0.9855479,0.01058605,0.001499998,0.00006460064,0.001294855,0.00001973172,0.00003704315,0.0002381227,0.00006933942,0.0001827917,0.0004406804,0.00001888251],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.966865,0.01175483,0.00129769,0.002240102,0.001411426,0.006938981,0.003060831,0.0001910591,0.006239966],"genre_scores_gemma":[0.98021,0.00482217,0.002302567,0.001728971,0.0006059773,0.00479932,0.001493092,0.00003185162,0.004006112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04787664,"threshold_uncertainty_score":0.09519595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03691251161864901,"score_gpt":0.3119401312248601,"score_spread":0.2750276196062111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}