{"id":"W4313225160","doi":"10.3390/v15010085","title":"Generation and Characterization of a SARS-CoV-2-Susceptible Mouse Model Using Adeno-Associated Virus (AAV6.2FF)-Mediated Respiratory Delivery of the Human ACE2 Gene","year":2022,"lang":"en","type":"article","venue":"Viruses","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; Canadian Food Inspection Agency; University of Manitoba; Public Health Agency of Canada","funders":"University of Toronto; Public Health Agency; Public Health Agency of Canada; Sunnybrook Research Institute; Canadian Food Inspection Agency","keywords":"Immune system; Immunology; Virology; Virus; Nasal administration; Biology; Antibody; Medicine; Pandemic; Lung; Disease; Infectious disease (medical specialty); Coronavirus disease 2019 (COVID-19); Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004155957,0.0001598333,0.0003207436,0.0002715598,0.0003021165,0.0000197073,0.0001748682,0.0001062144,0.00001232977],"category_scores_gemma":[0.0001194531,0.0001399429,0.0000841729,0.0005253638,0.0001427488,0.0001657461,0.0002408545,0.0002435966,0.000002055498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002066674,"about_ca_system_score_gemma":0.0003810915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006687557,"about_ca_topic_score_gemma":0.0001270748,"domain_scores_codex":[0.9981992,0.0002365356,0.0004391589,0.0002799719,0.0006126098,0.00023256],"domain_scores_gemma":[0.999051,0.0000326442,0.000315383,0.0003539078,0.0002253172,0.00002173346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001467847,0.0002561877,0.02031699,0.00004955529,0.00007726256,0.000003804064,0.0005287877,0.00008476885,0.9783283,0.00001701105,0.0001039242,0.00008666667],"study_design_scores_gemma":[0.001157114,0.0002561375,0.002700667,0.00002701905,0.00008001512,0.000002776204,0.00005853012,0.02373964,0.9710078,0.00001168671,0.000836732,0.0001219042],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987477,0.0002335878,0.00006923798,0.00002893124,0.00006459151,0.0004798468,0.0003060024,0.0000434696,0.0000266255],"genre_scores_gemma":[0.9866226,0.00001044074,0.00004723435,0.01312091,0.00006937737,0.00003682177,0.00003344281,0.00004280811,0.00001637442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02365487,"threshold_uncertainty_score":0.5706706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1617353187946024,"score_gpt":0.3615738891633983,"score_spread":0.199838570368796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}