{"id":"W4313225160","doi":"10.3390/v15010085","title":"Generation and Characterization of a SARS-CoV-2-Susceptible Mouse Model Using Adeno-Associated Virus (AAV6.2FF)-Mediated Respiratory Delivery of the Human ACE2 Gene","year":2022,"lang":"en","type":"article","venue":"Viruses","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; Canadian Food Inspection Agency; University of Manitoba; Public Health Agency of Canada","funders":"University of Toronto; Public Health Agency; Public Health Agency of Canada; Sunnybrook Research Institute; Canadian Food Inspection Agency","keywords":"Immune system; Immunology; Virology; Virus; Nasal administration; Biology; Antibody; Medicine; Pandemic; Lung; Disease; Infectious disease (medical specialty); Coronavirus disease 2019 (COVID-19); Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009650072,0.001368692,0.0007485496,0.001810962,0.0006444925,0.000889576,0.0009086776,0.001776948,0.003568425],"category_scores_gemma":[0.0003708526,0.0007368932,0.001019112,0.0003873219,0.0009228201,0.001065951,0.0005385022,0.003119268,0.001529215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006066548,"about_ca_system_score_gemma":0.0005482187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008651183,"about_ca_topic_score_gemma":0.001230544,"domain_scores_codex":[0.9990354,0.0001085266,0.0001508071,0.0003101146,0.000211016,0.0001842677],"domain_scores_gemma":[0.9994011,0.00005652267,0.0001492547,0.00007966528,0.00006824258,0.0002451985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004737738,0.0007306847,0.0004943623,0.0001155091,0.00002286272,0.0002905123,0.0001394711,0.0002036128,0.9939814,0.0009957241,0.0003056363,0.002246379],"study_design_scores_gemma":[0.0005362503,0.007505949,0.008168718,0.0001103551,0.0001680011,0.003302391,0.0003128591,0.005227164,0.9499193,0.0008409828,0.0238258,0.00008216091],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9306762,0.002810834,0.04998766,0.001222275,0.0006775169,0.001472269,0.00618053,0.0009189224,0.006053863],"genre_scores_gemma":[0.9040441,0.004192334,0.04989362,0.0009632179,0.0002217648,0.003503776,0.007871361,0.0003783144,0.02893147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003568425,"threshold_uncertainty_score":0.0119375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1617353187946024,"score_gpt":0.3615738891633983,"score_spread":0.199838570368796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}