{"id":"W4313236514","doi":"10.1038/s42255-022-00702-w","title":"mTORC1 takes control of lysosomal lipid breakdown","year":2022,"lang":"en","type":"letter","venue":"Nature Metabolism","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"","keywords":"mTORC1; Anabolism; Catabolism; Endosome; Lysosome; Cell biology; Metabolism; Chemistry; Biology; Biochemistry; Phosphorylation; Enzyme; Intracellular","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001694252,0.000961055,0.001044472,0.0006184534,0.00179598,0.002717495,0.0009204508,0.01267718,0.003170596],"category_scores_gemma":[0.005851158,0.0004711789,0.0007248275,0.0003524453,0.002202461,0.001946362,0.001053568,0.0144107,0.003043087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0026459,"about_ca_system_score_gemma":0.0009920846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001194059,"about_ca_topic_score_gemma":0.001775436,"domain_scores_codex":[0.9989844,0.0002096132,0.0000891036,0.0001427106,0.0003693925,0.0002047897],"domain_scores_gemma":[0.9982646,0.0008371932,0.000119024,0.0001223318,0.0003160335,0.0003408577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001465534,0.00007209118,0.0008437884,0.0002881267,0.00008369721,0.00472635,0.0001336865,0.000491366,0.00616292,0.02385483,0.9042615,0.05761603],"study_design_scores_gemma":[0.0005903551,0.000196443,0.002099389,0.0001789385,0.0000878607,0.002917763,0.0002143797,0.001844344,0.01282907,0.04586886,0.9330729,0.000099668],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.002988927,0.01614361,0.0009083983,0.8929033,0.0765715,0.0000253347,0.0001133378,0.0001475453,0.01019802],"genre_scores_gemma":[0.08484621,0.02311962,0.001690337,0.5713236,0.2784637,0.0001844232,0.0001274018,0.0001329514,0.04011177],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01267718,"threshold_uncertainty_score":0.0191974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003991373435343105,"score_gpt":0.2048531281957839,"score_spread":0.2008617547604408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}