{"id":"W4313236943","doi":"10.1056/nejmoa2206575","title":"Lentiviral Gene Therapy for Artemis-Deficient SCID","year":2022,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"National Institute of Allergy and Infectious Diseases; California Institute for Regenerative Medicine","keywords":"Genetic enhancement; Computational biology; Gene; Virology; Biology; Medicine; Cancer research; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001468581,0.0001365269,0.000364484,0.0001812081,0.0003911373,0.000005254239,0.000329508,0.00004610112,0.001060919],"category_scores_gemma":[0.0001101591,0.00009574717,0.000136902,0.000155969,0.0001533576,0.00005420651,0.00004017262,0.0004239019,0.000007956271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003833391,"about_ca_system_score_gemma":0.0001614261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004185042,"about_ca_topic_score_gemma":5.637955e-7,"domain_scores_codex":[0.9987832,0.000184526,0.0005000252,0.0001318524,0.0001189998,0.0002814547],"domain_scores_gemma":[0.9992095,0.0001801075,0.0003505128,0.0001539182,0.00009226286,0.00001365185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002506606,0.0002971626,0.0002646318,0.000007356924,0.000206994,0.00001672475,0.003618137,0.0003530584,0.6110923,0.0006013818,0.01783131,0.3632044],"study_design_scores_gemma":[0.06194012,0.003757722,0.00102269,0.00002925032,0.00006133874,0.001012895,0.00167488,0.000009122304,0.01533806,0.0009626453,0.9140524,0.000138931],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8413048,0.1450906,0.002116396,0.005311205,0.004963515,0.0002574335,0.00001509203,0.00001829359,0.0009227158],"genre_scores_gemma":[0.9958453,0.0004891987,0.00003699975,0.0006942975,0.0001445143,0.000007756382,0.00003717047,0.00001358524,0.002731142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.896221,"threshold_uncertainty_score":0.9998522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01856584392198194,"score_gpt":0.2523495390086795,"score_spread":0.2337836950866975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}