{"id":"W4313236943","doi":"10.1056/nejmoa2206575","title":"Lentiviral Gene Therapy for Artemis-Deficient SCID","year":2022,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"National Institute of Allergy and Infectious Diseases; California Institute for Regenerative Medicine","keywords":"Genetic enhancement; Computational biology; Gene; Virology; Biology; Medicine; Cancer research; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002296915,0.0003541585,0.0002413075,0.0003264812,0.0002115027,0.0003382362,0.0002674237,0.0004243396,0.0013658],"category_scores_gemma":[0.0002133252,0.00009954134,0.0003134078,0.0001805064,0.000359582,0.0001993996,0.0001946518,0.0006117302,0.00036848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003521382,"about_ca_system_score_gemma":0.0002283882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002833423,"about_ca_topic_score_gemma":0.0002805422,"domain_scores_codex":[0.9998958,0.00001912933,0.00001320937,0.00001952505,0.00003373803,0.00001861937],"domain_scores_gemma":[0.9998981,0.000018743,0.00004075508,0.00001595339,0.000007917115,0.00001853706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007878111,0.0003614461,0.002852884,0.0001814313,0.00006774317,0.001145543,0.0001097998,0.0006274676,0.9702505,0.0007934733,0.0007725583,0.02204942],"study_design_scores_gemma":[0.0004292149,0.005034194,0.01027763,0.00004790981,0.0001862212,0.01040858,0.00006175566,0.003976916,0.9499336,0.0002302074,0.0193947,0.00001909461],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893072,0.002162717,0.00541222,0.0001834505,0.00007113109,0.000160345,0.0005175216,0.0002591185,0.001926269],"genre_scores_gemma":[0.9926221,0.001081015,0.003347653,0.0001071103,0.00002552305,0.0001237207,0.0008234043,0.00002543472,0.001843994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0013658,"threshold_uncertainty_score":0.004569113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01856584392198194,"score_gpt":0.2523495390086795,"score_spread":0.2337836950866975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}