{"id":"W4313244961","doi":"10.3390/molecules28010212","title":"Designing Functionally Substituted Pyridine-Carbohydrazides for Potent Antibacterial and Devouring Antifungal Effect on Multidrug Resistant (MDR) Strains","year":2022,"lang":"en","type":"article","venue":"Molecules","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University","funders":"","keywords":"Antimicrobial; Fluconazole; Multiple drug resistance; Minimum inhibitory concentration; Microbiology; Chemistry; Colistin; Pseudomonas aeruginosa; Pharmacology; Antibiotics; Biology; Antifungal; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001291277,0.0002984685,0.0002091041,0.0001908585,0.0001178919,0.0001523616,0.0003313794,0.0002405883,0.001002483],"category_scores_gemma":[0.0001387454,0.0001149668,0.0001973786,0.000222094,0.0001518819,0.0002327563,0.0002023878,0.0003209007,0.0002771835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001460577,"about_ca_system_score_gemma":0.0001891753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003224722,"about_ca_topic_score_gemma":0.0009556122,"domain_scores_codex":[0.9999404,0.00001589254,0.000005917918,0.00001021063,0.00001187829,0.00001560348],"domain_scores_gemma":[0.9999602,0.00000500893,0.00001352993,0.000004829487,0.00000710627,0.000009242338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001829065,0.0001190036,0.0003101594,0.0002840987,0.00001402151,0.0004737551,0.00004160792,0.001037198,0.9864206,0.0008531422,0.0002035288,0.01006005],"study_design_scores_gemma":[0.0001135905,0.002411296,0.002692899,0.00003650347,0.00005077114,0.001015909,0.0000590723,0.002647437,0.977018,0.0002493004,0.01367859,0.000026626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789748,0.00596837,0.008607463,0.0002888895,0.00006609068,0.0001114181,0.000335181,0.0001002521,0.00554756],"genre_scores_gemma":[0.9855929,0.003944507,0.007993971,0.00007036428,0.00001429354,0.00004561219,0.0002393864,0.00001268692,0.002086157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001002483,"threshold_uncertainty_score":0.003353655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01205608297860829,"score_gpt":0.2368942710602513,"score_spread":0.224838188081643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}