{"id":"W4313246645","doi":"10.3390/cells12010076","title":"Advanced Maternal Age Differentially Affects Embryonic Tissues with the Most Severe Impact on the Developing Brain","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Pregnancy and preeclampsia studies","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Children's Hospital Research Institute","keywords":"Placentation; Transcriptome; Trophoblast; Embryo; Biology; Placenta; Fetus; Pregnancy; Embryonic stem cell; Andrology; Gestation; Physiology; Bioinformatics; Medicine; Cell biology; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001693876,0.0001751777,0.0002088226,0.00002624839,0.0004896846,0.00003006229,0.0002089591,0.00002120128,0.0002653284],"category_scores_gemma":[0.00001656848,0.00007673505,0.00006255453,0.0001486127,0.0000708922,0.00002951914,0.0001575601,0.0003126221,0.0000243469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000857346,"about_ca_system_score_gemma":0.00008160773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001761023,"about_ca_topic_score_gemma":0.00003223027,"domain_scores_codex":[0.9990264,0.0001510533,0.00007983474,0.0001877776,0.0002880935,0.0002668417],"domain_scores_gemma":[0.9992225,0.0003469077,0.00006758565,0.0003135854,0.00001208911,0.00003729805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.01389638,0.001034641,0.05866574,0.001819719,0.006688087,0.005526089,0.05696924,0.005832561,0.3145573,0.01133395,0.4126936,0.1109827],"study_design_scores_gemma":[0.007395647,0.004765724,0.7009723,0.002453955,0.0004758409,0.0005957951,0.004491392,0.0002116506,0.1541907,0.001212753,0.1219297,0.001304527],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842456,0.001112451,0.00007306038,0.008801818,0.0001759086,0.0005722879,0.00001576836,0.00005267525,0.004950445],"genre_scores_gemma":[0.9906757,0.00007543497,0.00006785139,0.002187492,0.00006879141,0.00008633149,0.000009170255,0.00002309176,0.006806165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6423066,"threshold_uncertainty_score":0.3766308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01277181661901082,"score_gpt":0.2579795194604804,"score_spread":0.2452077028414696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}