{"id":"W4313246645","doi":"10.3390/cells12010076","title":"Advanced Maternal Age Differentially Affects Embryonic Tissues with the Most Severe Impact on the Developing Brain","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Pregnancy and preeclampsia studies","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Children's Hospital Research Institute","keywords":"Placentation; Transcriptome; Trophoblast; Embryo; Biology; Placenta; Fetus; Pregnancy; Embryonic stem cell; Andrology; Gestation; Physiology; Bioinformatics; Medicine; Cell biology; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001031862,0.0001345422,0.0001676734,0.0002325422,0.0001046176,0.0002344318,0.00005989409,0.000131996,0.0006904615],"category_scores_gemma":[0.0001147815,0.00007323716,0.0001640086,0.0001277371,0.0001381372,0.0001209195,0.000173448,0.0002490415,0.00009630735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001200136,"about_ca_system_score_gemma":0.0001328674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004731196,"about_ca_topic_score_gemma":0.001040339,"domain_scores_codex":[0.9999245,0.0000102787,0.000005433739,0.00002710878,0.00001641633,0.00001618506],"domain_scores_gemma":[0.9999367,0.000008709511,0.00002737849,0.000005491092,0.000007133766,0.00001458596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003227115,0.00001871625,0.01165678,0.00005724346,0.00002647023,0.0002202978,0.0001130615,0.00003972345,0.9809126,0.0001365497,0.00008319141,0.006412633],"study_design_scores_gemma":[0.00001326337,0.0008277928,0.7373958,0.00005068863,0.0001369545,0.001349113,0.0006021967,0.0003199352,0.2529311,0.0004028492,0.005953377,0.00001695132],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955421,0.002441868,0.000787471,0.00006675471,0.00001459297,0.000006823651,0.000352357,0.00001188739,0.0007761304],"genre_scores_gemma":[0.9939935,0.002858018,0.0009727966,0.00009829199,0.00001348122,0.00002286021,0.0003995928,0.00001048943,0.001630886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006904615,"threshold_uncertainty_score":0.002309799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01277181661901082,"score_gpt":0.2579795194604804,"score_spread":0.2452077028414696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}