{"id":"W4313246952","doi":"10.26508/lsa.202201800","title":"Kindlin2 enables EphB/ephrinB bi-directional signaling to support vascular development","year":2022,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sinai Health System; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Institute of Neurological Disorders and Stroke; National Heart, Lung, and Blood Institute; Canada Research Chairs; Government of Canada; National Institutes of Health; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada","keywords":"Ephrin; Erythropoietin-producing hepatocellular (Eph) receptor; Cell biology; Zebrafish; Biology; Integrin; Signal transduction; Transmembrane protein; Intracellular; Population; Receptor tyrosine kinase; Receptor; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001602004,0.0002661314,0.0002515762,0.0002387185,0.002770079,0.0001949096,0.001646096,0.00003065694,0.001571544],"category_scores_gemma":[0.0008343285,0.0002787544,0.0001011686,0.002516042,0.0003394543,0.0006361995,0.0007814121,0.0003729336,0.0006028484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002938862,"about_ca_system_score_gemma":0.001490607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001043242,"about_ca_topic_score_gemma":0.000003078776,"domain_scores_codex":[0.9945325,0.0001289893,0.0005117513,0.001349376,0.002467255,0.001010089],"domain_scores_gemma":[0.998575,0.0001959054,0.0001730946,0.0004292744,0.0001027577,0.0005239771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000401307,0.0001137608,0.001232586,0.00001124324,0.000004447927,0.00005890821,0.000596744,0.02492791,0.9673817,0.001074923,0.0009427294,0.003614922],"study_design_scores_gemma":[0.0002598479,0.0001672116,0.001767184,0.00002345625,0.000005181703,0.00003581636,0.0001849715,0.0004762424,0.7426413,0.0001935971,0.2537785,0.0004666882],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922224,0.0001209779,0.002486833,0.0009409325,0.001280079,0.0004870572,0.0000162716,0.0002296491,0.002215749],"genre_scores_gemma":[0.9796615,0.00002525975,0.004430646,0.01364651,0.0001975894,0.0002512123,0.000002313003,0.00003063016,0.001754298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2528358,"threshold_uncertainty_score":0.9999664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06102364542288106,"score_gpt":0.2879068055348381,"score_spread":0.226883160111957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}