{"id":"W4313246952","doi":"10.26508/lsa.202201800","title":"Kindlin2 enables EphB/ephrinB bi-directional signaling to support vascular development","year":2022,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sinai Health System; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Institute of Neurological Disorders and Stroke; National Heart, Lung, and Blood Institute; Canada Research Chairs; Government of Canada; National Institutes of Health; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada","keywords":"Ephrin; Erythropoietin-producing hepatocellular (Eph) receptor; Cell biology; Zebrafish; Biology; Integrin; Signal transduction; Transmembrane protein; Intracellular; Population; Receptor tyrosine kinase; Receptor; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001447649,0.0002400517,0.0001734151,0.0003097033,0.0002694031,0.0002870858,0.0001560762,0.0001945661,0.001536344],"category_scores_gemma":[0.0001151461,0.0001689172,0.0001637059,0.00014326,0.0001437196,0.0002818298,0.0004614867,0.0003453668,0.0004876923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003412651,"about_ca_system_score_gemma":0.0002313037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005109544,"about_ca_topic_score_gemma":0.002158019,"domain_scores_codex":[0.9998223,0.00002658772,0.0000154342,0.00003437761,0.00006215809,0.00003920864],"domain_scores_gemma":[0.9999189,0.0000111744,0.00001596301,0.00001147628,0.00001071696,0.00003174871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002270266,0.000003938917,0.000171164,0.000008918668,0.00000243095,0.00005505052,0.00001103233,0.00002203213,0.9988375,0.0001951617,0.00005873357,0.0006113931],"study_design_scores_gemma":[0.00001328075,0.0000628806,0.005570223,0.000003649511,0.00001440716,0.000846924,0.00003119008,0.001178527,0.9834659,0.00011356,0.008693447,0.000005985955],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888636,0.0005509392,0.005007943,0.0001283648,0.00003982884,0.00003809827,0.0003496343,0.0001154611,0.004906088],"genre_scores_gemma":[0.9878714,0.0003887741,0.005456875,0.00006352746,0.00001262806,0.00005072285,0.0006373625,0.00004974396,0.005468918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001536344,"threshold_uncertainty_score":0.005139589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06102364542288106,"score_gpt":0.2879068055348381,"score_spread":0.226883160111957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}