{"id":"W4313251504","doi":"10.1038/s41392-022-01239-w","title":"SARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis","year":2022,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Fundamental Research Funds for the Central Universities; National Medical Research Council; National Natural Science Foundation of China","keywords":"Biology; RNA; Kinase; Cyclin-dependent kinase 2; Virology; Coronaviridae; Viral replication; RNA-dependent RNA polymerase; Cell biology; Subgenomic mRNA; Coronavirus disease 2019 (COVID-19); Genetics; Virus; Protein kinase A; Gene; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004895875,0.0002703797,0.0003690264,0.0003672624,0.0004068163,0.00004750899,0.000165487,0.00009335119,0.0006354766],"category_scores_gemma":[0.00001855191,0.0002472193,0.0001984238,0.0005967396,0.0000981876,0.0001096369,0.00002777674,0.0005012248,0.00004348503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001187598,"about_ca_system_score_gemma":0.0001498344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001571231,"about_ca_topic_score_gemma":0.000004638448,"domain_scores_codex":[0.9977896,0.0002124526,0.0003056447,0.0005580303,0.000666306,0.0004680185],"domain_scores_gemma":[0.9994288,0.00004476259,0.00004840528,0.0002974431,0.0000938533,0.00008672612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002310249,0.0003901565,0.0002284338,0.00003995966,0.0001469134,0.0001130846,0.001099512,0.000003687356,0.9402556,0.00008260131,0.0002980724,0.05503176],"study_design_scores_gemma":[0.00148793,0.001008775,0.0001328517,0.00001615131,0.00003193699,0.00004379787,0.0002178994,0.0001912344,0.7452354,0.0003101489,0.2511139,0.0002099428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926679,0.00196611,0.001110377,0.002166844,0.000271919,0.0009481671,0.00003937018,0.0001676149,0.0006617477],"genre_scores_gemma":[0.9807324,0.00004792276,0.0002901861,0.01819383,0.0002816401,0.0003012009,0.0000119794,0.00006011494,0.00008075844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2508158,"threshold_uncertainty_score":0.999998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03699022197621208,"score_gpt":0.3044330731505513,"score_spread":0.2674428511743392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}