{"id":"W4313251504","doi":"10.1038/s41392-022-01239-w","title":"SARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis","year":2022,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Fundamental Research Funds for the Central Universities; National Medical Research Council; National Natural Science Foundation of China","keywords":"Biology; RNA; Kinase; Cyclin-dependent kinase 2; Virology; Coronaviridae; Viral replication; RNA-dependent RNA polymerase; Cell biology; Subgenomic mRNA; Coronavirus disease 2019 (COVID-19); Genetics; Virus; Protein kinase A; Gene; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001334035,0.0004401829,0.0002668885,0.0001731412,0.0001971405,0.0004636008,0.0001433528,0.0001915164,0.001808002],"category_scores_gemma":[0.0001103893,0.0001080327,0.0002273618,0.0001125025,0.0001877629,0.0003617885,0.0002113855,0.0003266497,0.0005139033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004395621,"about_ca_system_score_gemma":0.0003782212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006751643,"about_ca_topic_score_gemma":0.001708204,"domain_scores_codex":[0.9999228,0.000008858937,0.00000474333,0.00002120318,0.00001600187,0.00002646738],"domain_scores_gemma":[0.9999613,0.000004865505,0.00001042617,0.000005018498,0.000006995645,0.00001142569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003550912,0.00005927271,0.001705699,0.0001250573,0.00001781897,0.0001802947,0.00001197941,0.0004504296,0.9898096,0.0006489181,0.0003799639,0.006255928],"study_design_scores_gemma":[0.00006283458,0.0003566744,0.01376672,0.00001969958,0.0000232511,0.0008269444,0.00006483059,0.004114761,0.9594408,0.0004415073,0.02086853,0.00001343996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9563493,0.02704431,0.005943892,0.0007782812,0.0001871219,0.00005946181,0.0009576638,0.000194286,0.008485762],"genre_scores_gemma":[0.9898455,0.004270155,0.002265784,0.0001191721,0.00002863965,0.00001760911,0.0004601608,0.0000151928,0.002977763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001808002,"threshold_uncertainty_score":0.006048322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03699022197621208,"score_gpt":0.3044330731505513,"score_spread":0.2674428511743392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}