{"id":"W4313263729","doi":"10.2196/37144","title":"Effectiveness of Secondary Risk–Reducing Strategies in Patients With Unilateral Breast Cancer With Pathogenic Variants of BRCA1 and BRCA2 Subjected to Breast-Conserving Surgery: Evidence-Based Simulation Study","year":2022,"lang":"en","type":"article","venue":"JMIR Formative Research","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Breast cancer; Medicine; Oncology; Internal medicine; Cancer; Stage (stratigraphy); Mastectomy; Cohort; Triple-negative breast cancer","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00784807,0.001118441,0.001785498,0.001105093,0.0002967983,0.00103822,0.001312907,0.001555307,0.003597494],"category_scores_gemma":[0.03240836,0.0006055947,0.004444152,0.0006434369,0.0005187038,0.0007960355,0.000801525,0.001487984,0.0001784834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003123616,"about_ca_system_score_gemma":0.0029403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01199573,"about_ca_topic_score_gemma":0.007129268,"domain_scores_codex":[0.9966186,0.002574758,0.0001992694,0.0002507396,0.000181956,0.0001746195],"domain_scores_gemma":[0.9522132,0.04201787,0.003592797,0.0005770292,0.0006926982,0.0009064197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.01144349,0.003202153,0.04063934,0.00143635,0.005843069,0.000237287,0.0001210092,0.9094256,0.0002668371,0.001670791,0.0006500985,0.025064],"study_design_scores_gemma":[0.00572592,0.01178901,0.01405201,0.0008010096,0.006484195,0.0002350369,0.00014311,0.9539785,0.0006647928,0.005032589,0.001025227,0.00006855447],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9720529,0.004501725,0.01637532,0.001183591,0.00007891918,0.0009115512,0.001734135,0.00005892015,0.003102867],"genre_scores_gemma":[0.9947373,0.0009674015,0.003162648,0.0001183789,0.00001399289,0.0003152555,0.0004727185,0.000004191535,0.0002081507],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01199573,"threshold_uncertainty_score":0.04150504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.020918133605624,"score_gpt":0.338044569258468,"score_spread":0.317126435652844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}