{"id":"W4313272658","doi":"10.3389/fimmu.2022.957233","title":"EGFR-targeted bacteriophage lambda penetrates model stromal and colorectal carcinoma tissues, is taken up into carcinoma cells, and interferes with 3-dimensional tumor formation","year":2022,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University of Waterloo","funders":"Canadian Institutes of Health Research; University of Waterloo","keywords":"Stromal cell; Cancer research; Tumor microenvironment; Immune system; Colorectal cancer; Biology; Epidermal growth factor; Cancer; Cancer cell; Spheroid; Confocal microscopy; Cell culture; Immunology; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006621591,0.0001694158,0.0001984852,0.0001244788,0.0001664354,0.00002506922,0.0001263702,0.00006593093,0.00002435172],"category_scores_gemma":[0.000005295576,0.0001488298,0.00002458648,0.00006998674,0.0001801695,0.00001806728,0.0002986419,0.0001718184,7.126194e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001076271,"about_ca_system_score_gemma":0.0001201217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006965807,"about_ca_topic_score_gemma":0.0003113973,"domain_scores_codex":[0.9989937,0.00009523186,0.0001591931,0.0003479591,0.0001056386,0.0002982915],"domain_scores_gemma":[0.9996879,0.000005993475,0.00006237307,0.0001538071,0.00003189829,0.00005807962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008553864,0.0004107518,0.1571815,0.00007520119,0.0003751344,0.0001916059,0.002223996,0.0001679315,0.8174532,0.0000224825,0.007695217,0.005649173],"study_design_scores_gemma":[0.01927198,0.009779846,0.1162558,0.00002470347,0.00007595879,0.0006418154,0.003896846,0.02212312,0.8209206,0.0004021831,0.005757235,0.0008498361],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911321,0.00801398,0.0001540136,0.00008122857,0.0001667922,0.0002633144,0.0001495813,0.000007223641,0.0000317113],"genre_scores_gemma":[0.9971501,0.0001432402,0.001835603,0.0000648507,0.00001645741,0.0001164186,0.0003900958,0.00001935099,0.0002639473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04092563,"threshold_uncertainty_score":0.6069103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005440956989477665,"score_gpt":0.2100582629705218,"score_spread":0.2046173059810441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}