{"id":"W4313278113","doi":"10.1002/anie.202214659","title":"Tunable Multivalent Platform for Immune Recruitment to Lower Antigen Expressing Cancers","year":2022,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Juravinski Cancer Centre","funders":"Natural Sciences and Engineering Research Council of Canada; Prostate Cancer Canada; Grantová Agentura České Republiky; Cancer Research Society","keywords":"Antigen; Immune system; Antibody; Avidity; Prostate cancer; Cancer research; Chemistry; Microfold cell; Immunology; Cancer; Biology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001632177,0.0003241446,0.0001576144,0.0001758736,0.00008457328,0.0002635756,0.0002743176,0.0003361297,0.001092913],"category_scores_gemma":[0.0001460548,0.0001321271,0.0001911681,0.0001156129,0.0001377305,0.0002382219,0.0003499664,0.0004020377,0.0004141112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000307631,"about_ca_system_score_gemma":0.0001206433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000148728,"about_ca_topic_score_gemma":0.0002431146,"domain_scores_codex":[0.9998698,0.00001956249,0.000007579361,0.00004198785,0.000032517,0.00002841118],"domain_scores_gemma":[0.9999311,0.00001241276,0.00002757176,0.000006861294,0.0000109671,0.00001113522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000393378,0.00001987038,0.0000472363,0.0000501254,0.000005391394,0.00002250521,0.00001096492,0.0002405469,0.9957598,0.0004312418,0.00008582829,0.003287276],"study_design_scores_gemma":[0.0000140521,0.0002529094,0.0002492917,0.000003786835,0.00001217886,0.00008020712,0.000005954825,0.00169156,0.993942,0.00005665762,0.003685281,0.000006062771],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9468247,0.002614292,0.04449463,0.0001852442,0.00005771628,0.0001101004,0.0002110894,0.0004493844,0.005053001],"genre_scores_gemma":[0.9770081,0.0006427427,0.01872924,0.00013189,0.00001453427,0.00008925143,0.0001177679,0.00002794288,0.003238501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001092913,"threshold_uncertainty_score":0.003656149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08814219093842306,"score_gpt":0.368483458096663,"score_spread":0.2803412671582399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}