{"id":"W4313278998","doi":"10.1016/j.jconrel.2022.12.009","title":"Prospects for hypoxia-based drug delivery platforms for the elimination of advanced metastatic tumors: From 3D modeling to clinical concepts","year":2022,"lang":"en","type":"review","venue":"Journal of Controlled Release","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Victoria","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; National Institute for Medical Research Development; BC Cancer Foundation; Tabriz University of Medical Sciences","keywords":"Hypoxia (environmental); Tumor hypoxia; Tumor microenvironment; Medicine; Prodrug; Metastasis; Drug; Tirapazamine; Bench to bedside; Clinical trial; Drug delivery; Cancer research; Bioinformatics; Pharmacology; Radiation therapy; Cancer; Tumor cells; Pathology; Biology; Internal medicine; Medical physics; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00190876,0.0003812329,0.002619822,0.0001552035,0.0001402609,0.00002992557,0.0005330422,0.000156369,0.00002244668],"category_scores_gemma":[0.002672282,0.0002381516,0.002462981,0.0001228034,0.00005603897,0.00001312832,0.00006368409,0.0003691989,5.998834e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006797096,"about_ca_system_score_gemma":0.001722036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006402732,"about_ca_topic_score_gemma":0.00001212451,"domain_scores_codex":[0.9965851,0.0001818869,0.002155391,0.0003713824,0.000392181,0.0003140901],"domain_scores_gemma":[0.9948142,0.001535462,0.002406969,0.0004022496,0.0006393635,0.0002017219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01297834,0.0003052028,3.45499e-7,0.001601489,0.00186258,0.000004174155,0.00004486791,0.01489997,0.00056936,0.00003116048,0.002136865,0.9655656],"study_design_scores_gemma":[0.02304783,0.001419688,7.847347e-7,0.001478731,0.005473604,0.00001478188,0.000141061,0.01138119,0.0002050918,0.0001964336,0.9562725,0.0003682563],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003249876,0.9579914,0.0317794,0.00007905588,0.002237772,0.004157648,0.0004938173,0.00000419159,0.000006879659],"genre_scores_gemma":[0.004083624,0.9837895,0.007302465,0.0003245965,0.003094347,0.0009463931,0.0002212406,0.00008216185,0.0001556969],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9651974,"threshold_uncertainty_score":0.9711542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04395359315933176,"score_gpt":0.3636937850050245,"score_spread":0.3197401918456927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}