{"id":"W4313279453","doi":"10.1158/1055-9965.epi-22-0763","title":"Genome-wide Interaction Study with Smoking for Colorectal Cancer Risk Identifies Novel Genetic Loci Related to Tumor Suppression, Inflammation, and Immune Response","year":2022,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Lunenfeld-Tanenbaum Research Institute","funders":"Office of Research Infrastructure Programs, National Institutes of Health; National Center for Advancing Translational Sciences; National Institute of Environmental Health Sciences; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institute on Aging; NIHR Imperial Biomedical Research Centre; Instituto de Salud Carlos III; Ontario Ministry of Research and Innovation; National Health and Medical Research Council; National Institute of Diabetes and Digestive and Kidney Diseases; World Cancer Research Fund; Medical Research Council; Centers for Disease Control and Prevention; World Health Organization; Xarxa de Bancs de Tumors de Catalunya; Junta de Castilla y León; National Institutes of Health; Groupement des Entreprises Françaises dans la lutte contre le Cancer; Centre Hospitalier Universitaire de Nantes; Medizinische Universität Graz; Grantová Agentura České Republiky; Herzfelder'sche Familienstiftung; Institut Gustave-Roussy; National Human Genome Research Institute; Cancer Council Victoria; School of Public Health, Imperial College London; Deutsche Krebshilfe; Associazione Italiana per la Ricerca sul Cancro; Vetenskapsrådet; Harvard T.H. Chan School of Public Health; Karolinska Institutet; Ministerstvo Zdravotnictví Ceské Republiky; Canadian Institutes of Health Research; Cancerfonden; Johns Hopkins University; Centre International de Recherche sur le Cancer; Canadian Cancer Society Research Institute; Institut National de la Santé et de la Recherche Médicale; Conseil Régional des Pays de la Loire; University of Pittsburgh; University of Cambridge; Cancer Research UK; Food Standards Agency; Bundesministerium für Bildung und Forschung; Swedish Cancer Foundation; Damon Runyon Cancer Research Foundation; Karl-Franzens-Universität Graz; Univerzita Karlova v Praze; McGill University; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institute for Health and Care Research; Division of Cancer Prevention, National Cancer Institute; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Association Anne de Bretagne Genetique; Brigham and Women's Hospital; Fred Hutchinson Cancer Research Center; Imperial College London; U.S. Department of Health and Human Services","keywords":"Colorectal cancer; Genotype; Single-nucleotide polymorphism; Confidence interval; Medicine; Internal medicine; Oncology; Locus (genetics); Population; Cancer; Gene; Genetics; Gastroenterology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001556531,0.0006962529,0.0008380432,0.001145073,0.0006014454,0.0007944828,0.0005953778,0.0008420222,0.003416903],"category_scores_gemma":[0.004398572,0.0003061033,0.002373046,0.001577997,0.0004220267,0.000241632,0.0006793594,0.00100945,0.0002022906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000281958,"about_ca_system_score_gemma":0.000518885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003581548,"about_ca_topic_score_gemma":0.005791572,"domain_scores_codex":[0.9979901,0.0008605135,0.0001479927,0.0005531046,0.0002348841,0.0002133567],"domain_scores_gemma":[0.9950836,0.002619943,0.001092846,0.0004358412,0.0002564571,0.0005113531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003232201,0.0000928182,0.9793475,0.00009758651,0.0052493,0.0005592793,0.0001001526,0.0002169189,0.007123123,0.0001045682,0.000256572,0.003619895],"study_design_scores_gemma":[0.00008935168,0.0003522165,0.9946537,0.00001472002,0.002465579,0.0005707255,0.00004770534,0.0007339842,0.0005310372,0.0001629822,0.0003650426,0.00001296021],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957049,0.00167645,0.001125307,0.0001774132,0.00003356796,0.00001465424,0.0007614621,0.00003767465,0.0004684497],"genre_scores_gemma":[0.998579,0.0001807341,0.0005303356,0.00004972696,0.00002292213,0.00002091124,0.0004129285,0.00001181639,0.0001915008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003581548,"threshold_uncertainty_score":0.01143068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01618172037430749,"score_gpt":0.3176869936673976,"score_spread":0.3015052732930901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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