{"id":"W4313281288","doi":"10.1089/dna.2022.0578","title":"Targeting Notch-Driven Cytokine Secretion: Novel Therapies for Triple Negative Breast Cancer","year":2022,"lang":"en","type":"article","venue":"DNA and Cell Biology","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Queen's University; University Health Network","funders":"","keywords":"Triple-negative breast cancer; Biology; Cancer research; Breast cancer; Notch signaling pathway; Chemokine; Immunotherapy; Immune system; Cytokine; Immune checkpoint; Immunology; Cancer; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001940614,0.0001842168,0.000294644,0.00006599538,0.0005765522,0.000007328476,0.0001980205,0.000162025,0.002807174],"category_scores_gemma":[0.00001189058,0.0001641778,0.00007940962,0.0001020876,0.0002821349,0.00003563593,0.0001885193,0.0002842612,0.00001434481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000702362,"about_ca_system_score_gemma":0.00007031445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002178136,"about_ca_topic_score_gemma":0.00001372909,"domain_scores_codex":[0.998827,0.0001549318,0.0002359514,0.0003768555,0.00001903682,0.0003862251],"domain_scores_gemma":[0.999418,0.0001975868,0.0001563357,0.0001480637,0.0000647492,0.00001528762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004790885,0.00008030893,0.0009585612,0.00002022458,0.0001356508,5.48367e-7,0.00131555,0.00004632033,0.9890018,0.0004780319,0.003609684,0.003874212],"study_design_scores_gemma":[0.005926285,0.0006127437,0.001433225,0.000009839148,0.0000829928,0.00005938511,0.00277269,0.0001226595,0.2698016,0.0005424271,0.7181576,0.0004785982],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9547534,0.02716167,0.001623769,0.002688945,0.006894504,0.001190305,0.004081785,0.0001355753,0.001470031],"genre_scores_gemma":[0.994218,0.000643728,0.0001931057,0.0007441956,0.0001464956,0.0005048375,0.0005610033,0.00002448629,0.002964141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7192003,"threshold_uncertainty_score":0.9981044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01148183312685153,"score_gpt":0.2385474565013526,"score_spread":0.2270656233745011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}