{"id":"W4313299661","doi":"10.1002/jbmr.4762","title":"Reduction of New Heterotopic Ossification ( <scp>HO</scp> ) in the <scp>Open‐Label</scp> , Phase 3 <scp>MOVE</scp> Trial of Palovarotene for Fibrodysplasia Ossificans Progressiva ( <scp>FOP</scp> )","year":2022,"lang":"en","type":"article","venue":"Journal of Bone and Mineral Research","topic":"Heterotopic Ossification and Related Conditions","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; University Health Network","funders":"Ipsen","keywords":"Fibrodysplasia ossificans progressiva; Medicine; Adverse effect; Interim analysis; Heterotopic ossification; Internal medicine; Hazard ratio; Post-hoc analysis; Clinical endpoint; Surgery; Randomized controlled trial; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.004924738,0.0003683147,0.001082156,0.001284137,0.000592593,0.0002039411,0.0007047612,0.0003507782,0.00003022127],"category_scores_gemma":[0.005581092,0.0002768964,0.00037199,0.001604784,0.0004682729,0.0004609282,0.0002061788,0.001924023,0.000006051741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002269525,"about_ca_system_score_gemma":0.001279068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001785027,"about_ca_topic_score_gemma":0.00001601168,"domain_scores_codex":[0.9934926,0.001007733,0.002138355,0.0005952877,0.001900548,0.0008654474],"domain_scores_gemma":[0.9939817,0.002184736,0.001455555,0.0007824255,0.001076877,0.0005186833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001702651,0.009610607,0.001868165,0.0009118035,0.0008474299,0.0002653,0.01740989,0.00009135804,0.7265583,0.00218158,0.1983908,0.04016219],"study_design_scores_gemma":[0.1742594,0.02766091,0.02499875,0.001364725,0.0008548097,0.002672172,0.0381876,0.001689877,0.0783894,0.003876307,0.6459078,0.0001382657],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881119,0.0016652,0.0002359678,0.002323802,0.0005147329,0.004775279,0.0001122153,0.00002068457,0.002240259],"genre_scores_gemma":[0.9642402,0.0009984603,0.001350595,0.0001385721,0.001228797,0.0008027069,0.0001844722,0.00007037184,0.03098582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6481689,"threshold_uncertainty_score":0.9999683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1409354639171878,"score_gpt":0.4274136020203913,"score_spread":0.2864781381032036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}