{"id":"W4313299661","doi":"10.1002/jbmr.4762","title":"Reduction of New Heterotopic Ossification ( <scp>HO</scp> ) in the <scp>Open‐Label</scp> , Phase 3 <scp>MOVE</scp> Trial of Palovarotene for Fibrodysplasia Ossificans Progressiva ( <scp>FOP</scp> )","year":2022,"lang":"en","type":"article","venue":"Journal of Bone and Mineral Research","topic":"Heterotopic Ossification and Related Conditions","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; University Health Network","funders":"Ipsen","keywords":"Fibrodysplasia ossificans progressiva; Medicine; Adverse effect; Interim analysis; Heterotopic ossification; Internal medicine; Hazard ratio; Post-hoc analysis; Clinical endpoint; Surgery; Randomized controlled trial; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001311662,0.0004977493,0.0007867687,0.000293459,0.000179445,0.000545103,0.0003504513,0.0007586342,0.003765496],"category_scores_gemma":[0.000917209,0.0003122956,0.001108797,0.0001696036,0.0003369498,0.0004037538,0.000238416,0.00173811,0.0004294369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003155226,"about_ca_system_score_gemma":0.0007218881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000751078,"about_ca_topic_score_gemma":0.003030892,"domain_scores_codex":[0.9996493,0.0001499364,0.00001844913,0.00005296807,0.00006805374,0.0000613373],"domain_scores_gemma":[0.9996452,0.0001040909,0.0001035314,0.00003275508,0.00002837028,0.00008597728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6612254,0.02046743,0.006695484,0.001991523,0.002221556,0.0002517806,0.0003033156,0.00272606,0.05885979,0.0008951614,0.006371343,0.2379912],"study_design_scores_gemma":[0.4824997,0.4508698,0.03789257,0.0003351135,0.001589177,0.00081036,0.000190158,0.003664487,0.01350361,0.0009664581,0.007617388,0.0000611556],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915605,0.003425342,0.0007463965,0.0002627214,0.00009956177,0.0008149857,0.0008441109,0.000130755,0.002115629],"genre_scores_gemma":[0.9929379,0.001388872,0.001211145,0.0003854523,0.00004907271,0.0007545825,0.0009201082,0.00002257626,0.00233032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003765496,"threshold_uncertainty_score":0.01259685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1409354639171878,"score_gpt":0.4274136020203913,"score_spread":0.2864781381032036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}