{"id":"W4313311915","doi":"10.1161/circresaha.122.321177","title":"RyR2 Serine-2030 PKA Site Governs Ca 2+ Release Termination and Ca 2+ Alternans","year":2022,"lang":"en","type":"article","venue":"Circulation Research","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta","funders":"Canadian Institutes of Health Research; Cumming School of Medicine, University of Calgary; Heart and Stroke Foundation of Canada; University of Calgary; Alberta Innovates; Generalitat de Catalunya; National Natural Science Foundation of China","keywords":"Calcium; Chemistry; Biophysics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001060194,0.0002327541,0.000393076,0.0004278002,0.0008836695,0.00006454686,0.0001457635,0.0001563442,0.001333038],"category_scores_gemma":[0.0004568418,0.0002455779,0.0001681576,0.0007735522,0.0002122151,0.0002445472,0.000292366,0.001194777,0.0002402379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005389651,"about_ca_system_score_gemma":0.0003348503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007315246,"about_ca_topic_score_gemma":0.00001522555,"domain_scores_codex":[0.9964129,0.0006382166,0.0003827874,0.0007039536,0.001158828,0.0007033615],"domain_scores_gemma":[0.9983349,0.0003211524,0.0000887641,0.0006037685,0.0003519702,0.000299442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.002825382,0.0008812274,0.06865773,0.0009848378,0.0006028005,0.004029803,0.01736062,0.7906089,0.02999314,0.001809564,0.0502874,0.03195863],"study_design_scores_gemma":[0.003525329,0.0009430478,0.1536458,0.00009021298,0.0001245088,0.001357992,0.001976511,0.8049994,0.0004318436,0.0007750568,0.0316264,0.0005039572],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923707,0.0004288614,0.00007217756,0.003792958,0.00006740423,0.0008709198,0.000144507,0.00008018463,0.002172342],"genre_scores_gemma":[0.9935983,0.000152065,0.00003906131,0.0005112537,0.0006589135,0.0002145963,0.0006461564,0.00005353695,0.004126059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08498808,"threshold_uncertainty_score":0.9999996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02810668215881086,"score_gpt":0.3266534745404869,"score_spread":0.2985467923816761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}