{"id":"W4313311915","doi":"10.1161/circresaha.122.321177","title":"RyR2 Serine-2030 PKA Site Governs Ca 2+ Release Termination and Ca 2+ Alternans","year":2022,"lang":"en","type":"article","venue":"Circulation Research","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta","funders":"Canadian Institutes of Health Research; Cumming School of Medicine, University of Calgary; Heart and Stroke Foundation of Canada; University of Calgary; Alberta Innovates; Generalitat de Catalunya; National Natural Science Foundation of China","keywords":"Calcium; Chemistry; Biophysics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001675684,0.0003563065,0.0002908341,0.000173131,0.0001549063,0.0002634816,0.0003269344,0.0004382039,0.001128522],"category_scores_gemma":[0.0001594035,0.0001929615,0.0003137926,0.00009615191,0.0005395527,0.0001853514,0.0002951628,0.0005267368,0.0005057498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003595338,"about_ca_system_score_gemma":0.0002292202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000380282,"about_ca_topic_score_gemma":0.0005452649,"domain_scores_codex":[0.9998595,0.00001787096,0.00002036031,0.00003667327,0.00004054919,0.00002507233],"domain_scores_gemma":[0.9996651,0.00003839565,0.000165216,0.00002220333,0.00001977845,0.00008928676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006916404,0.000007633179,0.0001543333,0.00001068585,0.000002564703,0.00006514796,0.000005012568,0.00004486422,0.9993886,0.00006813755,0.00001263711,0.0001711205],"study_design_scores_gemma":[0.00003354648,0.0001831177,0.007462232,0.000008609674,0.0000202917,0.0006234351,0.00002627826,0.001804077,0.9887017,0.0001040273,0.001022889,0.000009674829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971452,0.0002211822,0.00167023,0.00005966793,0.00001539734,0.00001719282,0.0001819898,0.00006360729,0.0006255361],"genre_scores_gemma":[0.9975574,0.0001334062,0.00137357,0.00005441436,0.000008121432,0.00002470625,0.0001831444,0.00003888552,0.0006263903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001128522,"threshold_uncertainty_score":0.003775299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02810668215881086,"score_gpt":0.3266534745404869,"score_spread":0.2985467923816761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}