{"id":"W4313313134","doi":"10.1038/s43018-022-00486-8","title":"DUSP6 mediates resistance to JAK2 inhibition and drives leukemic progression","year":2022,"lang":"en","type":"article","venue":"Nature Cancer","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Center for Advancing Translational Sciences; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Heart, Lung, and Blood Institute; National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; Government of Canada; MPN Research Foundation; Canadian Institutes of Health Research; Leukemia and Lymphoma Society","keywords":"Cancer research; Myeloid leukemia; PTEN; Janus kinase; DUSP6; Biology; Kinase; Myeloid; Signal transduction; Phosphatase; PI3K/AKT/mTOR pathway; Cell biology; Protein phosphatase 2; Phosphorylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002410314,0.0002685968,0.0002975358,0.0002982225,0.0002616796,0.0008551906,0.0003255745,0.0003918342,0.003421057],"category_scores_gemma":[0.000296312,0.0002270984,0.000242872,0.0002690776,0.0003507359,0.0002986774,0.000400982,0.001828325,0.0009177759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006074182,"about_ca_system_score_gemma":0.0003664023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000599299,"about_ca_topic_score_gemma":0.001161231,"domain_scores_codex":[0.9996718,0.00006296918,0.00002115743,0.0000467317,0.00008848874,0.0001087481],"domain_scores_gemma":[0.9997947,0.00003264658,0.00004049656,0.00003549021,0.00001690558,0.00007975101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007444024,0.0002685376,0.002511362,0.0001005128,0.00003234602,0.0002626461,0.0000508414,0.0008919613,0.975239,0.002581017,0.002140159,0.01517722],"study_design_scores_gemma":[0.0002348968,0.001310263,0.0149246,0.00002027518,0.0000434972,0.002151486,0.0002377369,0.007352196,0.9427888,0.001153942,0.02976349,0.00001879787],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986586,0.002894903,0.001872816,0.0008294467,0.0001049322,0.00004454548,0.001045498,0.0003019358,0.006320059],"genre_scores_gemma":[0.996534,0.0005751564,0.0003916581,0.00007656789,0.00001235769,0.00001565338,0.000545849,0.00001867944,0.001830091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003421057,"threshold_uncertainty_score":0.01144463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008970861050342492,"score_gpt":0.3290423090391962,"score_spread":0.3200714479888537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}