{"id":"W4313313134","doi":"10.1038/s43018-022-00486-8","title":"DUSP6 mediates resistance to JAK2 inhibition and drives leukemic progression","year":2022,"lang":"en","type":"article","venue":"Nature Cancer","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Center for Advancing Translational Sciences; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Heart, Lung, and Blood Institute; National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; Government of Canada; MPN Research Foundation; Canadian Institutes of Health Research; Leukemia and Lymphoma Society","keywords":"Cancer research; Myeloid leukemia; PTEN; Janus kinase; DUSP6; Biology; Kinase; Myeloid; Signal transduction; Phosphatase; PI3K/AKT/mTOR pathway; Cell biology; Protein phosphatase 2; Phosphorylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002488694,0.0001337345,0.0002030503,0.0001792973,0.0002245572,0.00001783029,0.00009184009,0.0001555118,0.0004547708],"category_scores_gemma":[0.0001807007,0.0001124382,0.00003596903,0.000509245,0.00007229475,0.00007250508,0.0002179141,0.001312833,0.00000920285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001147988,"about_ca_system_score_gemma":0.0004442375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001872842,"about_ca_topic_score_gemma":0.00006640318,"domain_scores_codex":[0.9984664,0.00006692768,0.0001469717,0.0003893643,0.0006292618,0.0003010867],"domain_scores_gemma":[0.9993297,0.00006865841,0.00005259037,0.000222954,0.0001231153,0.0002030005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003078564,0.0001205719,0.02425833,0.0004474633,0.0001048422,0.0004330162,0.002479669,0.00003770465,0.3329795,0.001229252,0.5990476,0.03578348],"study_design_scores_gemma":[0.004672258,0.0005854541,0.08074208,0.0006915538,0.00009438241,0.0001139354,0.0008392813,0.0001751971,0.09045756,0.0006585476,0.8204816,0.000488175],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9538381,0.01935214,0.000008461553,0.02386475,0.0002961719,0.0007558352,0.00006964568,0.0000895899,0.001725305],"genre_scores_gemma":[0.987842,0.0006595496,0.001039507,0.003903177,0.0004411336,0.0005438153,0.00006245811,0.00003465426,0.005473763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2425219,"threshold_uncertainty_score":0.5703681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008970861050342492,"score_gpt":0.3290423090391962,"score_spread":0.3200714479888537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}